Bazı 1-[(N,N-disübstüetiyokarboniltiyo)asetil]-3-(2-tiyenil)-5-aril-2-pirazolin türevlerinin sentezleri ve antifungal, antibakteriyel etkilerinin araştırılması
Synthesis of some 1-[(N,N-disubstituted-thiocarbonylthio)acetyl]-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives and investigation of their antifungal, antibacterial activities
- Tez No: 158322
- Danışmanlar: PROF.DR. GÜLHAN TURAN
- Tez Türü: Doktora
- Konular: Eczacılık ve Farmakoloji, Pharmacy and Pharmacology
- Anahtar Kelimeler: Dithiocarbamate, 2-Pyrazoline, Antifungal activity
- Yıl: 2004
- Dil: Türkçe
- Üniversite: Anadolu Üniversitesi
- Enstitü: Sağlık Bilimleri Enstitüsü
- Ana Bilim Dalı: Farmasötik Kimya Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: Belirtilmemiş.
Özet
The literature research on dithiocarbamate derivatives showed that these compounds have antifungal and antibacterial activities. It is also well known that pyrazoline derivatives show antibacterial and antifungal activities. In our study, it has been aimed that the synthesis and antimicrobial evaluation of new l-[(N,N-disubstituted thiocarbamoylthio)acetyl]-3-(2-thienyl)- 5~aryl-2-pyrazoline derivatives which include dithiocarbamate and pyrazoline moieties. Desired original twenty-eight compounds were synthesized by reacting l-(2-chloroacetyl)-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives with dithio- carbamates having initial substances. Physical properties, Rf values on thin layer chromatography, Rt values on high pressure liquid chromatography and UV absorption properties of the compounds have been determined and their structure has been elucidated by IR, 'H-NMR, MS spectra and elemental analysis. Promising results have been obtained from the in-vitro antifungal and antibacterial activities of eighteen compounds, which include some of the starting and resulted compounds.
Özet (Çeviri)
ABSTRACT PhD. Thesis SYNTHESIS OF SOME 1-[(N, N-DISUBSTITUTED THIOCARBONYLTHIO) ACETYL]- 3-(2-TfflENYL)-5-ARYL-2-PYRAZOLINE DERIVATIVES AND INVESTIGATION OF THEIR ANTIFUNGAL, ANTIBACTERIAL ACTIVITIES Msc. Pharm. Ahmet OZDEMIR Anadolu University Institute of Health Sciences Department of Pharmaceutical Chemistry Supervisor: Prof. Dr. Gülhan TURAN 2004 mABSTRACT PhD. Thesis SYNTHESIS OF SOME 1-[(N, N-DISUBSTITUTED THIOCARBONYLTHIO) ACETYL]- 3-(2-TfflENYL)-5-ARYL-2-PYRAZOLINE DERIVATIVES AND INVESTIGATION OF THEIR ANTIFUNGAL, ANTIBACTERIAL ACTIVITIES Msc. Pharm. Ahmet OZDEMIR Anadolu University Institute of Health Sciences Department of Pharmaceutical Chemistry Supervisor: Prof. Dr. Gülhan TURAN 2004 m
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