Siyah çayın karbon tekraklorür uygulanan sıçanlarda lipid peroksidasyonu üzerine etkisi
Effect of black tea on lipid peroxidation in carbon tetrachloride treated rats
- Tez No: 355236
- Danışmanlar: DOÇ. DR. DEHEN SÜR ALTINER
- Tez Türü: Yüksek Lisans
- Konular: Biyokimya, Biochemistry
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 1998
- Dil: Türkçe
- Üniversite: Marmara Üniversitesi
- Enstitü: Sağlık Bilimleri Enstitüsü
- Ana Bilim Dalı: Biyokimya Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 61
Özet
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Özet (Çeviri)
The aim of our study was to investigate the inhibitory effect of black tea on CC4 (1 ml/kg, i.p.) induced lipid peroxidation bearing in mind sexual differences between the animals. In addition the effect of CCl4 in causing hepatic injury by inducing lipid peroxidation was examined, again bearing in mind sexual differences.“Control”,“CCI4 ”and“Black Tea+CCI4 ”groups were made up from both male and female rats. The rats in the“Black Tea+CCI4 ”group were fed the basal diet with 6% black tea for 2 months. The rats in the“Control”group were treated with olive oil and the rats in the two other groups were treated with CCI4. They were killed 2 hours after these treatments. Their plasma AL T and AST activities were measured by auto analyzer. Plasma and liver lipid peroxide levels were measured by thiobarbituric acid test. Liver glutathione levels were measured by the Ellman's method. According to our investigations, CCl4 treatment caused significant increases in plasma AL T and AST activities and liver lipid peroxide levels in males and females, but CCl4 treatment did not cause a significant increase in plasma lipid peroxide levels under experimental conditions. A significant increase in glutathione levels in males was observed, but a significant difference in females was not determined under experimental conditions. These findings showed that CCl4 caused hepatic injury and induced lipid peroxidation in liver both in males and females, but this lipid peroxidation was not detected in plasma under experimental conditions. It was considered that an increase in glutathione level in males in response to lipid peroxidation in liver, was earlier than that in females. Black tea caused significant differences in neither the plasma lipid peroxide levels of males nor of females but it significantly decreased liver lipid peroxide levels in CCl4 treated males and females. In addition to that black tea showed a decreasing effect in ALT, AST activities and in the light of these findings it was suggested that black tea lessened the hepatic injury. Black tea decreased the glutathione level in CCl4 treated males. As a result of this finding, it was speculated that black tea may have decreased the lipid peroxide level in liver and in response to this decrease the glutathione level remained low. In females, no significant difference was observed in glutathione levels. Also, when males and females in the“Control”group were compared, it was observed that there were no significant differences between their lipid peroxide levels. However, glutathione levels in females compared to males were significantly lower. In the light of this finding it was concluded that the glutathione level which was already lower in females than in males did not fall further under experimental conditions.
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