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Microfluidic continuous separation of particles and cells by AC-dielectrophoresis

Başlık çevirisi mevcut değil.

  1. Tez No: 400137
  2. Yazar: BARBAROS ÇETİN
  3. Danışmanlar: PROF. DONGQİNG Lİ
  4. Tez Türü: Doktora
  5. Konular: Makine Mühendisliği, Mechanical Engineering
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2009
  8. Dil: İngilizce
  9. Üniversite: Vanderbilt University
  10. Enstitü: Yurtdışı Enstitü
  11. Ana Bilim Dalı: Belirtilmemiş.
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 118

Özet

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Özet (Çeviri)

AC-dielelectrophoresis is utilized inside a lab-on-a-chip device for the continuous separationof particles and cells. Dielectrophoresis is the movement of particles in non-uniform electric fieldsdue to the interaction of the particle?s dipole and spatial gradient of the electric field. Dielectrophoresisis a subtle solution to manipulate particles and cells at microscale due to its favorablescaling for reduced size of the system. Dielectrophoretic force depends on the particle volume,electrical properties of the particle and the medium, and field frequency in the case of AC-field.Therefore, it is possible to separate particles and cells based on their size and their electrical properties.In this dissertation, the continuous separation of particles and cells based on their size andbased on their electrical properties is demonstrated. PDMS (polydimethylsiloxane) microchannelsare fabricated using soft lithography technique. Simple, 3D electrodes which are fabricatedby a simple and inexpensive technique extended from the soft-lithographic fabrication are usedto achieve a localized, non-uniform electric field. The localized field is important to reduce theJoule heating and any adverse effects on biological particles due to the interaction of particles withthe electric field. Latex particles of different size and mixture of white blood cells (which have atypical size of 8?12?m) and yeast cells (which have a typical size of 3?5?m) is separated basedon their size difference. The separation based on electrical properties is demonstrated by meansof the separation of 10?m latex particles and white blood cells. A numerical simulation basedon Lagrangian tracking method is used to simulate the particle trajectories. The designs have theadvantages of being fabricated by easy and inexpensive technique like DC-DEP devices; and ofusing low electrical potential like AC-DEP devices. It would be unique in a sense that the effect ofthe electric field is confined in a small area.

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