Effects of porosity on mechanical properties of a bone substitute material
Başlık çevirisi mevcut değil.
- Tez No: 402848
- Danışmanlar: DR. IRENE G. TURNER
- Tez Türü: Yüksek Lisans
- Konular: Makine Mühendisliği, Mechanical Engineering
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2015
- Dil: İngilizce
- Üniversite: University of Bath
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 84
Özet
Özet yok.
Özet (Çeviri)
A number of medical areas currently utilise bioceramic materials in applications, such as otology, facial procedures (craniofacial and maxillofacial), dentistry and orthopaedics. Nevertheless, those bioceramics formed of certain materials have contained a substantial component of isolated pores. These include hydroxyapatite (HA) and tricalcium phosphate (TCP). These pores have either limited ingrowth of bone or invoked insufficient mechanical characteristics for use in bearing loads [1]. One material that does perform better in terms of allowing ingrowth of tissue is porous calcium phosphate, offering a potential alternative in artificial grafts. How successful these are depends crucially on both pore size and the connective potential between tissue and graft. Certain studies have indicated that the latter is more significant of the two. As standard, pore sizes of ≥100 μm represent a baseline for a sufficient level of functionality in porous implant components and ≥200 μm allows for osteoconduction. Nevertheless, a more porous structure is typically mechanically weaker. So it can be seen that equity must be achieved between the influences of physical structure and biological uptake. The real task is to obtain the optimum and sufficient of both interconnective and porous properties. Significant influences on this type of feature include repair methods, remodelling and degrading rates in supporting structural components [2-7]. This thesis aims to explore various granule types that are commercially available via their mechanical properties and the influence of different porous levels, specifically 25% and 50%. Immersion of granules in simulated body fluid (SBF) is used to evaluate the level and features of granule deterioration in vitro; providing data on the relevance and potential of their use in human osteology, including bearing of loads. Two granule sets were arranged into porosity values of 25% and 50% respectively then placed in simulated body fluid solution for the following time periods: 0, 3 days, 1, 2, 4 and 6 weeks. The mass was then measured for each time period sample, whilst the change in pore size over time was observed via an Scanning Electron Microscopy (SEM). It is predicted that at either porosity the sample would gain mass with time immersed, yet between the two the 50% porosity sample achieved this gain more gradually. Both samples were shown to reduce in pore size with time immersed; in this case the 25% sample proving less favourable in terms of yielded porosity distribution based on standard osteological replacement uses. To approach the mechanical properties of the different granules from another angle, the varying porosity samples were compressed to 1000 N over the time periods and the strain in each recorded. The patterns are as follows: At 50% porosity the strain values saw a slow rise up to the 2 weeks immersion sample, subsequently falling up to the 4 weeks sample but with a great increase up to 6 weeks. At 25% porosity the 3 days immersion sample showed a falling strain level with a subsequent rise continuing until the 4 weeks period before falling again up to 6 weeks. In the light of the information given above, granules with 50% porosity have shown a lower increase in mass compared to granules with 25% porosity. In addition, the final pore size distribution in 50% porosity granules ensures successful bone formation. Last of all, observing higher strain values in 50% porosity samples offers a more suitable candidate for load bearing service conditions.
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