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Köpeklerde deneysel olarak oluşturulan septik şokun sağaltımında Dobutamine, Flunixin, Meglumine, Methylprednisolone ve Enalapril'in etkileri

Başlık çevirisi mevcut değil.

  1. Tez No: 58874
  2. Yazar: ZEKİ YILMAZ
  3. Danışmanlar: DOÇ. DR. HASAN BATMAZ
  4. Tez Türü: Doktora
  5. Konular: Veteriner Hekimliği, Veterinary Medicine
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 1997
  8. Dil: Türkçe
  9. Üniversite: Uludağ Üniversitesi
  10. Enstitü: Sağlık Bilimleri Enstitüsü
  11. Ana Bilim Dalı: İç Hastalıkları (Veterinerlik) Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 83

Özet

SUMMARY In experimentally septic shock induced dogs, establishment of early diagnostic criteria and comparison of the affects of different treatment combinations at the beginning of the septic shock were aimed in this study. Thirty dogs of both sexes and different ages were used in the study. To clinically and hematologically controlled each dogs, 5x1 09 Escherichia coli bacteria/kg were given via intravenous route and approximately within one hour the septic shock was induced. Five groups each composed of 6 dogs were designed, and to I th group (control group) only antibiotic and fluid therapy was performed. To rest of the groups, along with antibiotic and fluid therapy, at the beginning dobutamin (10 meg/kg/min, i.v.) was given. Additionally, methylprednisolone sodium succinate (in the shock phase 30 mg/kg, i.v.), flunixin meglumin (in the shock phase and 2 nd and 12 th hours of the shock 1.5 mg/kg, i.v.), and enalapril (after 24 th hour 0.5 mg/kg, Per oral in every 12 hours), were utilized to the III. rd, IV. th and V. th groups, respectively. All the dogs were examined regarding for clinical, hematological and biochemical parameters before and at the septic shock phase and also at the 1 st, 4 th. 12 th, 24 th, 36 th, 48 th, 72 nd, 96 th and 120 th hours after the application of first treatment. Plasma volume was calculated from hematocrit and hemoglobin values. During the septic shock high fever, increased heart and respiratory rates, weakned heart beat and peripheral pulse, prolonged capillary refilling time, leukopenia, neutropenia, thrombocytopenia, plasma volume decrease and increased hematocrit (p

Özet (Çeviri)

SUMMARY In experimentally septic shock induced dogs, establishment of early diagnostic criteria and comparison of the affects of different treatment combinations at the beginning of the septic shock were aimed in this study. Thirty dogs of both sexes and different ages were used in the study. To clinically and hematologically controlled each dogs, 5x1 09 Escherichia coli bacteria/kg were given via intravenous route and approximately within one hour the septic shock was induced. Five groups each composed of 6 dogs were designed, and to I th group (control group) only antibiotic and fluid therapy was performed. To rest of the groups, along with antibiotic and fluid therapy, at the beginning dobutamin (10 meg/kg/min, i.v.) was given. Additionally, methylprednisolone sodium succinate (in the shock phase 30 mg/kg, i.v.), flunixin meglumin (in the shock phase and 2 nd and 12 th hours of the shock 1.5 mg/kg, i.v.), and enalapril (after 24 th hour 0.5 mg/kg, Per oral in every 12 hours), were utilized to the III. rd, IV. th and V. th groups, respectively. All the dogs were examined regarding for clinical, hematological and biochemical parameters before and at the septic shock phase and also at the 1 st, 4 th. 12 th, 24 th, 36 th, 48 th, 72 nd, 96 th and 120 th hours after the application of first treatment. Plasma volume was calculated from hematocrit and hemoglobin values. During the septic shock high fever, increased heart and respiratory rates, weakned heart beat and peripheral pulse, prolonged capillary refilling time, leukopenia, neutropenia, thrombocytopenia, plasma volume decrease and increased hematocrit (p

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