Secretory and anti-inflammatory actions of some gastro-intestinal hormones in salivary glands
Başlık çevirisi mevcut değil.
- Tez No: 622354
- Danışmanlar: PROF. DR. DANIŞMAN YOK
- Tez Türü: Doktora
- Konular: Eczacılık ve Farmakoloji, Pharmacy and Pharmacology
- Anahtar Kelimeler: Salivary glands, protein secretion, synthesis, inflammation, β-defensins, myeloperoxidase, cholecystokinin, gastrin, melatonin, nitric oxide, nerve stimulation
- Yıl: 2009
- Dil: İngilizce
- Üniversite: Göteborgs Universitet (The University of Gothenburg)
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 50
Özet
Textbooks generally state that the secretory activity of salivary glands is solely regulated by nerves. This view is challenged in the present Thesis, using the parotid gland of the anaesthetized rat as experimental in vivo model. By changing focus from secretion of fluid to secretion of protein and of acinar amylase a secretory role was found not only for gastrin and cholecystokinin but also for the non-traditional gastro-intestinal hormone melatonin. Neither intravenous infusion of the hormone-analogues pentagastrin and desulfated cholecystokinin-8 nor of melatonin evoked any overt fluid secretion from the duct-cannulated gland. However, a subsequent intravenous wash-out injection of the secretagogue methacholine revealed protein/amylase secretion in response to the infusion of the hormone/hormone-analogues. The hormone/hormone-analogues exerted their effect directly on the gland cells: it persisted in the presence of α- and β-adrenoceptor antagonists, after disconnecting the gland from its peripheral ganglia and after evisceration. The gland protein synthesis increased to pentagastrin. Cholecystokinin(CCK) -A and CCK-B receptor types as well as the melatonin receptors, MT1 and MT2, were expressed in the gland. By the use of hormone-receptor antagonists, protein secretion was shown to involve mainly the CCK-A receptors and the MT2 receptors, whereas both types of cholecystokinin receptors were involved in the protein synthesis. The secretion of protein/amylase and the synthesis of protein to the hormone/ hormone-analogues were partially dependent on nitric oxide generated by the activity of neuronal type NO-synthase, probably of parenchymal origin. Cholecystokinin may occur as a transmitter in the peripheral nervous system and, hypothetical, cholecystokinin might belong to the group of parasympathetic non-adrenergic, non-cholinergic transmitters that upon stimulation of the parasympathetic auriculo-temporal nerve evokes secretion of fluid and, in particular, secretion of protein/amylase. However, the stimulation of the parasympathetic innervation, in the presence of cholecystokinin receptor antagonists, gave no support for a transmitter role for cholecystokinin in the gland. Lipopolysaccharide injected intraductally towards the parotid gland induced inflammation, as shown by neutrophil infiltration and increased myeloperoxidase activity in the gland, and mobilization of β-defensins, being a part of the oral defense mechanism. Melatonin and cholecystokinin (sulphated CCK-8) administered intraperitoneally exerted anti-inflammatory actions in the inflamed gland as judged by reduced levels of the elevated activity of myeloperoxidase. The effect of melatonin was nonreceptor mediated, while that of sulphated CCK-8 was partially dependent on CCK-A receptors. The inflammatory response involved NO generated from inducible NO-synthase and neuronal type of NO-synthase as shown by selective NO-synthase inhibitors, the neuronal type being most likely of parenchymal origin, since it was activated also in the chronically denervated gland. In conclusion, the secretory activity of salivary glands seems not only to be regulated by a cephalic phase of nervous activity but also by a gastric phase and an intestinal phase of endocrine activity. Circulating melatonin and cholecystokinin/gastrin may not only influence the secretory activity but may also protect the salivary glands from inflammation. The present findings have implications for salivary gland dysfunction/dry mouth and its treatment.
Özet (Çeviri)
Özet çevirisi mevcut değil.
Benzer Tezler
- Retroperitoneal yağ dokusu denervasyonunu takiben diyetle obez yapılmış sıçanlarda adiponektin gen ekspresyonu ve serum seviyelerinin incelenmesi
The investigation of adiponectin gene expressions and serum levels in diet induced obese rats subsequent to retroperitoneal adipose tissue denervation
NESLİHAN SAĞLAM
Yüksek Lisans
Türkçe
2016
BiyokimyaKaradeniz Teknik ÜniversitesiTıbbi Biyokimya Ana Bilim Dalı
PROF. DR. AHMET ALVER
- Mezenkimal kök hücrelerin kimyasal olarak indüklenmiş endometrial yaşlanma modeli üzerine etkisi
Effect of mesenchymal stem cells on chemically-induced endometrial senescent model
MUHAMMED YUSUF PEKMEZCİ
Yüksek Lisans
Türkçe
2019
Histoloji ve EmbriyolojiManisa Celal Bayar ÜniversitesiHistoloji ve Embriyoloji Ana Bilim Dalı
PROF. DR. HAFİZE SEDA VATANSEVER
- Investigation of the effects of HIV-1 tat gene on the expression of Secretory Leucocyte Protease Inhibitor in Primate Cell Lines.
HIV-1 tat geninin, primat hücrelerindeki salgısal lekosit proteaz inhibitörünün ifadelenmesi üzerine olan etkisinin incelenmesi.
SELÇUK ÖZDEMİR
Doktora
İngilizce
2015
Genetikİzmir Yüksek Teknoloji EnstitüsüMoleküler Biyoloji ve Genetik Ana Bilim Dalı
DOÇ. DR. ALPER ARSLANOĞLU
- Tıkanma ikteri yapılan ratlarda etanercept'in karaciğer hücrelerine ve apoptoza etkilerinin araştırılması
Investigation of the effects of etanercept on hepatic cells and apoptosis in rats with obstructive jaundice
ERKAN KARACAN
Tıpta Uzmanlık
Türkçe
2018
Genel CerrahiAdnan Menderes ÜniversitesiGenel Cerrahi Ana Bilim Dalı
PROF. DR. PARS TUNÇYÜREK
- Nöral tip kalsiyum kanal blokörü zikonotid ve ibuprofen kombinasyonun antiinflamatuvar etkinliğinin in vitro araştırılması
In vitro investigation of anti-inflammatory efficacy of neural-type calcium channel blocker ziconotide ve ibuprofen combination
LİN OSMAN
Yüksek Lisans
Türkçe
2022
Eczacılık ve FarmakolojiErciyes ÜniversitesiEczacılık Farmakoloji Ana Bilim Dalı
PROF. DR. M. BETÜL AYCAN