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Renal transplant hastalarında endotelyal nitrik oksit sentaz geni Glu298Asp. intrun 4 ve -786T>C polimorfizmleri, arteriyel sertlik ve karotis intima-media kalınlığı

Endothelial nitric oxide synthase gene Glu298Asp, intron 4 and -186>C polymorphisms, arterial stiffness and carotid intima-media thickness in renal transplant patients

  1. Tez No: 171444
  2. Yazar: İHSAN ERGÜN
  3. Danışmanlar: PROF.DR. BÜLENT ERBAY
  4. Tez Türü: Tıpta Uzmanlık
  5. Konular: Nefroloji, Nephrology
  6. Anahtar Kelimeler: carotid intima-media thickness, endothelial nitric oxide synthase gene, pulse wave velocity, renal transplantation, vascular stiffness 29, carotid intima-media thickness, endothelial nitric oxide synthase gene, pulse wave velocity, renal transplantation, vascular stiffness 29
  7. Yıl: 2006
  8. Dil: Türkçe
  9. Üniversite: Ankara Üniversitesi
  10. Enstitü: Tıp Fakültesi
  11. Ana Bilim Dalı: Nefroloji Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 40

Özet

7. SUMMARY Endothelial Nitric Oxide Synthase Gene, Glu298Asp, Intron 4 and -786T>C Polymorphisms, Arterial Stiffness and Carotid Intima-media Thickness in Renal Transplant Patients Atherosclerotic cardiovascular disease is a leading cause of mortality in renal transplant patients. Carotid-femoral pulse wave velocity (c-f PWV), a measure of aortic arterial stiffness and carotid intima-media thickness (CIMT) are strongly associated with atherosclerosis, and correlate well with cardiovascular risk factors. Endothelial nitric oxide synthase (eNOS) gene, Glu298Asp, intron 4 and - 786T>C polymorphisms affects nitric oxide synthesis and has been reported to be a risk factor for atherosclerosis both in patients with renal failure and in general population. In this study, we evaluated the relationship between Glu298Asp, -786T>C, intron 4 polymorphisms of the eNOS gene and increased arterial stiffness and CIMT (early markers of atherosclerosis) in renal transplant patients. A total of 109 consecutive patients who received their first kidney transplantation and maintained graft function (creatinineC genotypes between the patients and the healthy controls. Sistolic blood pressure (95% CI: 0.006-0.037; p=0.007), body mass index (95% CI: 0.041-0.169; p=0.001) and male gender (95% CI: 0.109-1.191; p=0.019) were found to be independent predictors of c-f PWV, while age (95% CI: 0.008- 280.013; pC polymorphisms and early markers of atherosclerosis (arterial stiffness and CIMT). In conclusion, on the contrary of the data found in patients with renal failure and in the general population, we failed to show any relation of eNOS genotype to arterial stiffness and CIMT in renal transplant patients.

Özet (Çeviri)

7. SUMMARY Endothelial Nitric Oxide Synthase Gene, Glu298Asp, Intron 4 and -786T>C Polymorphisms, Arterial Stiffness and Carotid Intima-media Thickness in Renal Transplant Patients Atherosclerotic cardiovascular disease is a leading cause of mortality in renal transplant patients. Carotid-femoral pulse wave velocity (c-f PWV), a measure of aortic arterial stiffness and carotid intima-media thickness (CIMT) are strongly associated with atherosclerosis, and correlate well with cardiovascular risk factors. Endothelial nitric oxide synthase (eNOS) gene, Glu298Asp, intron 4 and - 786T>C polymorphisms affects nitric oxide synthesis and has been reported to be a risk factor for atherosclerosis both in patients with renal failure and in general population. In this study, we evaluated the relationship between Glu298Asp, -786T>C, intron 4 polymorphisms of the eNOS gene and increased arterial stiffness and CIMT (early markers of atherosclerosis) in renal transplant patients. A total of 109 consecutive patients who received their first kidney transplantation and maintained graft function (creatinineC genotypes between the patients and the healthy controls. Sistolic blood pressure (95% CI: 0.006-0.037; p=0.007), body mass index (95% CI: 0.041-0.169; p=0.001) and male gender (95% CI: 0.109-1.191; p=0.019) were found to be independent predictors of c-f PWV, while age (95% CI: 0.008- 280.013; pC polymorphisms and early markers of atherosclerosis (arterial stiffness and CIMT). In conclusion, on the contrary of the data found in patients with renal failure and in the general population, we failed to show any relation of eNOS genotype to arterial stiffness and CIMT in renal transplant patients.

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