Cerrahi girişim sonrası batın içi yapışıklıkların önlenmesinde povidon, hyskon, Ca++ antagonisti ve vitamin E'nin yeri (deneysel çalışma)
Başlık çevirisi mevcut değil.
- Tez No: 17930
- Danışmanlar: Belirtilmemiş.
- Tez Türü: Tıpta Uzmanlık
- Konular: Genel Cerrahi, General Surgery
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 1991
- Dil: Türkçe
- Üniversite: İstanbul Üniversitesi
- Enstitü: Tıp Fakültesi
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 47
Özet
SUMMARY The effect of vitamin E, vitamin C and selenium on the various tissue antioxidant systems of STZ-induced diabetic rats. Diabetes Mellitus is a metabolic disease which has a cronic progress due to the insufficiency on the absence or either the non activity of the insulin hormone. This disease is characterized by a humoral, microangypathy histological variations like hyperglycemi and ketonemi. Due to this disease metabolic disorders of the carbohydrate metabolism and the protein, lipid and electrolyte metabolism may occur. There are many symptoms of this disease. These symptoms are vascular, eye, kidney,neurosystem, ketoacidose and the decrease of the resistance against infections and skin complications. In this study, we examined the effect of vitamin E, vitamin C and selenium on the lenses, liver, kidney, heart, skin and on the blood glucose, glutathione and on the serum total lipid, cholesterol and proteins of diabetic rats. For this purpose 2-2.5 month old Swiss albino rats were used. The rats were divided into two groups of diabetic and two groups of control. The animals were made diabetic by intraperitoneal injection of 65 mg/kg STZ (streptozotocin) in citrate buffer (pH=4.5). From day 1 to day 30, 250mg/kg vitamin E, 250 mg/kg vitamin C and 0.2 mg/kg sodyum selenate were given daily by gavage technicque to one of the control and diabetic group. After STZ injection at 1., 10., 20. and 30. days tail blood samples were taken fasting blood glucose and glutathione levels were determined by o-toluidin and Beutler Duron Kelly method, respectively. At 0. and 30. days serum total lipid, cholesterol and protein levels were determined by sulfo phospho vanilin, Zak and Lowry methods, respectively. At 30. day STZ injections the rats were sacrificed by giving excess ether. Protein, lipid peroxidation, glutathione and nonenzymatic glycosylation of lens, liver, kidney, skin and heart proteins were determined by Lowry, Ledwazwy, EUman and thiobarbituric acid methods, respectively. Due to the results the increased levels of NEG and LPO of the lens, kidney, heart, liver tissues of the diabetic rats had decreased, and the decreased levels of GSH in the skin and lens had increased with by the usage of vitamin E, vitamin C and selenium.
Özet (Çeviri)
SUMMARY The effect of vitamin E, vitamin C and selenium on the various tissue antioxidant systems of STZ-induced diabetic rats. Diabetes Mellitus is a metabolic disease which has a cronic progress due to the insufficiency on the absence or either the non activity of the insulin hormone. This disease is characterized by a humoral, microangypathy histological variations like hyperglycemi and ketonemi. Due to this disease metabolic disorders of the carbohydrate metabolism and the protein, lipid and electrolyte metabolism may occur. There are many symptoms of this disease. These symptoms are vascular, eye, kidney,neurosystem, ketoacidose and the decrease of the resistance against infections and skin complications. In this study, we examined the effect of vitamin E, vitamin C and selenium on the lenses, liver, kidney, heart, skin and on the blood glucose, glutathione and on the serum total lipid, cholesterol and proteins of diabetic rats. For this purpose 2-2.5 month old Swiss albino rats were used. The rats were divided into two groups of diabetic and two groups of control. The animals were made diabetic by intraperitoneal injection of 65 mg/kg STZ (streptozotocin) in citrate buffer (pH=4.5). From day 1 to day 30, 250mg/kg vitamin E, 250 mg/kg vitamin C and 0.2 mg/kg sodyum selenate were given daily by gavage technicque to one of the control and diabetic group. After STZ injection at 1., 10., 20. and 30. days tail blood samples were taken fasting blood glucose and glutathione levels were determined by o-toluidin and Beutler Duron Kelly method, respectively. At 0. and 30. days serum total lipid, cholesterol and protein levels were determined by sulfo phospho vanilin, Zak and Lowry methods, respectively. At 30. day STZ injections the rats were sacrificed by giving excess ether. Protein, lipid peroxidation, glutathione and nonenzymatic glycosylation of lens, liver, kidney, skin and heart proteins were determined by Lowry, Ledwazwy, EUman and thiobarbituric acid methods, respectively. Due to the results the increased levels of NEG and LPO of the lens, kidney, heart, liver tissues of the diabetic rats had decreased, and the decreased levels of GSH in the skin and lens had increased with by the usage of vitamin E, vitamin C and selenium.
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