Deneysel olarak karbonmonoksit zehirlenmesi oluşturulan ratlarda miyokard hasarının şiddeti ile B tipi natriüretik peptid ve kardiyak troponin I düzeyleri arasındaki ilişki
The relationship between the severity of myocardial injury and the levels of B type natriuretic peptide and cardiac troponin I in rats experimentally exposed to carbon monoxide
- Tez No: 192234
- Danışmanlar: DOÇ.DR. LEVENT AVŞAROĞULLARI
- Tez Türü: Tıpta Uzmanlık
- Konular: İlk ve Acil Yardım, Emergency and First Aid
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2006
- Dil: Türkçe
- Üniversite: Erciyes Üniversitesi
- Enstitü: Tıp Fakültesi
- Ana Bilim Dalı: Acil Tıp Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 47
Özet
zehirlenme grupları) cTnI düzeyleri yüksek saptandı ancak sadece grup 4 ilearalarındaki fark istatistiksel olarak anlamlı bulundu (p
Özet (Çeviri)
THE RELATIONSHIP BETWEEN THE SEVERITY OFMYOCARDIAL INJURY AND THE LEVELS OF B TYPENATRIURETIC PEPTIDE AND CARDIAC TROPONIN IIN RATS EXPERIMENTALLY EXPOSED TOCARBON MONOXIDEABSTRACTAim: In this study, our purpose was to determine whether plasma B typenatriuretic peptide (BNP) level can be useful or not in determining the severity ofmyocardial injury formed by carbon monoxide (CO) poisoning and to compareplasma BNP level with serum cardiac troponin I (cTnI) level.Materials and methods: In the study, 46 female Vistar Albino rats weighing210-235 gr were used. Rats were divided into four groups, one sham group and threepoisoning groups. Groups included 10 rats in sham group and 12 rats in poisoninggroups. The rats to be poisoned with CO were placed in an anesthesia chamber. Themixture of pure CO and air was injected with 3 lt/min speed for 60 minutes toprovide 3000 ppm CO concentration in the chamber. After this period rats weretaken out of the chamber into normal atmosphere. The rats which died during or afterthe poisoning were excluded from the study. Blood samples of sham group werecollected both to measure carboxyhemoglobin (COHb), BNP and cTnI levels and tocompare with poisoning groups. Blood samples of poisoning groups were collectedat the 1st, 6th and 12th hours after poisoning. After biochemical procedures, findingswere analysed statistically and compared with each other.viiResults: Eight rats which died in poisoning groups were excluded from thestudy and 38 rats out of 46 were evaluated. COHb levels were rather high in Group 2(1st hour poisoning group) compared to Group 1 (Sham group) and the differencebetween groups was statistically significant (p
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