Aydın ilinde 2006 yılında doğan bebeklerde işitme kaybı sıklığı ve ilişkili risk faktörleri
The incidence of newborn hearing loss and related risk factors in Aydin province in 2006
- Tez No: 204238
- Danışmanlar: Y.DOÇ.DR. MUSTAFA İLHAN
- Tez Türü: Yüksek Lisans
- Konular: Halk Sağlığı, Public Health
- Anahtar Kelimeler: Sıklık, İşitme kaybı, newborn hearing loss, screening, incidence, Density, Hearing loss
- Yıl: 2007
- Dil: Türkçe
- Üniversite: Gazi Üniversitesi
- Enstitü: Sağlık Bilimleri Enstitüsü
- Ana Bilim Dalı: Halk Sağlığı Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: Belirtilmemiş.
Özet
The oxidatve protein damage provoked by reactve ree radicals has been demonstrated o play a signicant role n several pathological events such as diabetes. Proteins can also be damaged by oxygen and nirogen radicals, eading o a oss of enzymatc actviy and the conversion of amno acids to carbonyl derivatves and t has already been shown hat ree radicals cause oxidaton of protein - H groups. Considerable evidence ndicates hat he maintenance of protein redox status s of fundamental mportance or cell functon, herefore structural changes n proteins are considered o be among he molecular mechanisms eading o diabetc complcatons, in he present study, we determned he efect of pridoindole stobadine supplementaton (STB; 24.7 mg/kg/day) on he markers of oxidatve protein damage n he ver ssue of TZ- diabetc rats and heir control and reated groups. Dabetes was nduced by ntraperitonal njecton of streptozotosin (55 mg/kg) and rats were randomy divided nto our groups as olows: control (K; n = 7), controlSTB (KTB; n=7), Dabet (DiA; n=7) and DabetSTB (DTB; n=7). 3- Nrotyrosine evels were measured by ELiSA. Thiols and AOPP evels of ver homogenates were studied by spectrophotometric methodand Protein carbonyl levels were determned by colorimetric assay kit. Total, protein and non-protein hiol levels were signicanty decreased n diabetc rats. On he other hand protein carbonyl content and advanced oxidaton protein product levels were signicanty ncreased n diabetc group compared w h hose of he controls (p<0,05). obadine reatment ed o signicanty ncrease hiol parameters and decreased protein carbonyl content and advanced oxidaton protein product (AOPP) evels n diabetSTB group (p<0.05). 3-nirotyrosine evels weren't dierent in all groups. Tssue protein oxidaton parameters n he our groups of Wstar-Abino rats were compared using he Mann-Whiney U-test. When not specied p<0.05 was considered signicant. The resuls of his study suggest hat obadine decreased oxidatve stres and may be efectve n preventng oxidatve protein damage, which may contribute to the development of diabetc complcatons.
Özet (Çeviri)
Congenital hearing loss causes very significant problems by the blockage of learning of speech and language skills. The incidence of newborn hearing loss is higher than all diseases screened in newborn, and ranges 1-3/1000. At present, there are technologies to be able to detect hearing loss in newborns. The early rehabilitation of permanent hearing loss in the first 6 months greatly differs from the rehabilitation performed after 6 months in terms of language skills. For this reason, the necessity of newborn hearing screening is accepted by all authorities. The aim of our study is to determine the incidence of newborn hearing loss in Aydın. All newborns were involved into the study who were admitted the center of newborn hearing loss screening center at the Zübeyde Hanım Obstetrics and Children Hospital between January 01 and December 31 2006. Totally 4.797 delivery were performed in the city center. Of these newborns, 4.497(93.7) were screened for newborn hearing loss at the Zübeyde Hanım Obstetrics and Children Hospital The age of screened newborns ranged 1-210 days. Of these, 4497 (93.7%) were evaluated for hearing loss by two trained general practitioners. In the screening centers where both of two screening devices were present, transient otoacoustic emissions (TOAE) were measured at first on the day before discharge. If the newborn failed TOAE, auditory brainstem response (ABR) test was performed. Newborns with risk factor(s) had both TOAE and ABR tests. The distribution of risk factors that reported reasons of hearing loss in newborns at screening population was as follows; relationship was the first reason at 346 (7.7%) newborns, ototoxic drug usage was the second (165 newborns, 3.7%), hyperbilirubinemia was the third (107newborns, 2.4%), hereditary sensorial hearing loss was the fourth (87newborns, 1.9%). As a result, of screened 4.497 newborn, 25 newborns (0.55%) were referred to the third-step-health-care system for further examination. After the evaluation at Dokuz Eylül University, hearing loss was diagnosed in 7 (0.15%) newborns. The incidence of newborn hearing loss in Aydın was found 1.5/1000.
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