Geri Dön

Üçüncü kuşak sefalosporin ve kinolon türevi kemoterapötiklerin immun yanıt üzerine etkilerinin araştırılması

Başlık çevirisi mevcut değil.

  1. Tez No: 23977
  2. Yazar: M.RIZA OMMATY
  3. Danışmanlar: PROF. DR. AHMET AKIN
  4. Tez Türü: Doktora
  5. Konular: Eczacılık ve Farmakoloji, Pharmacy and Pharmacology
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 1992
  8. Dil: Türkçe
  9. Üniversite: Ankara Üniversitesi
  10. Enstitü: Sağlık Bilimleri Enstitüsü
  11. Ana Bilim Dalı: Farmasötik Biyokimya Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 80

Özet

63 SUMMARY Recently it is suggested that chemotherapeutics have not only antimic robial activities, but also they are effective on the functions of the immuno- component cells as well. în this research the effects of 6 antimicrobial agents, mainly third generation cephalosporines and Quinolon derivatives, and a known immunosuppressive drug were studied at the humoral and cellular base. These were Ceftriaxone, Ceftazidime and Cefotaxime (third generation Cephalosporine), Ciprofloxacin (third generation Quinolon), Fluconazole (antimycotic), Amikacin (antimicrobial) and Cyclophosphamide (immuno- suppressive). The effects of these drugs on immune response at the humoral base were studied by means of antibody levels and by examining the PPD reac tions after BCG vaccinating of PPD negative rabbits at the cellular base. The in-vivo antibody results of these agents againts Salmonella typhi H and O antigents are summerized in table 2-9, the cellular immune respon se results are described in table 10 and the graphics are shown in figures 1-14 and 15-21 respectively. Two different control groups were used in order to make a certaine re ference. The humoral response was suppressed after a short stimulation fase by Ceftriaxone. This suppression is not as high as that get by Cyclophosphami de, however, it is meaningful yet. So it seems to be a untitled delayed supp ression on the immune response at the humoral base, wherease it is at a high level at the cellular base. Applying Ceftazidim, the humoral response was not affected, where the cellular response was suppressed as high as that of Ceftriaxone. în the case of Ciprofloxacin, the humoral response was suppressed ra-64 pidly after a short period of stimulation. The cellular response, however, is directly stimulated. Cephotaxime suppressed particularly both the humoral and the cellu- lar responses. The humoral response was not affected by Fluconazol, in spite of the cellular response which was lowly suppressed in long term. The last agent was Amikacin. The humoral response was suppressed in long term. Delayed hypersensitivity of cellular response was fifthy percently suppressed. Although it is hard to state the immune response totally, either humo ral or cellular, because the matter is not known completely and the data are not satisfying, this is a fact that any drug which is highly taken to the organi- sim, will effect the immune system. So it is important not to use any anti microbial agent or other therapeutics by chance.

Özet (Çeviri)

63 SUMMARY Recently it is suggested that chemotherapeutics have not only antimic robial activities, but also they are effective on the functions of the immuno- component cells as well. în this research the effects of 6 antimicrobial agents, mainly third generation cephalosporines and Quinolon derivatives, and a known immunosuppressive drug were studied at the humoral and cellular base. These were Ceftriaxone, Ceftazidime and Cefotaxime (third generation Cephalosporine), Ciprofloxacin (third generation Quinolon), Fluconazole (antimycotic), Amikacin (antimicrobial) and Cyclophosphamide (immuno- suppressive). The effects of these drugs on immune response at the humoral base were studied by means of antibody levels and by examining the PPD reac tions after BCG vaccinating of PPD negative rabbits at the cellular base. The in-vivo antibody results of these agents againts Salmonella typhi H and O antigents are summerized in table 2-9, the cellular immune respon se results are described in table 10 and the graphics are shown in figures 1-14 and 15-21 respectively. Two different control groups were used in order to make a certaine re ference. The humoral response was suppressed after a short stimulation fase by Ceftriaxone. This suppression is not as high as that get by Cyclophosphami de, however, it is meaningful yet. So it seems to be a untitled delayed supp ression on the immune response at the humoral base, wherease it is at a high level at the cellular base. Applying Ceftazidim, the humoral response was not affected, where the cellular response was suppressed as high as that of Ceftriaxone. în the case of Ciprofloxacin, the humoral response was suppressed ra-64 pidly after a short period of stimulation. The cellular response, however, is directly stimulated. Cephotaxime suppressed particularly both the humoral and the cellu- lar responses. The humoral response was not affected by Fluconazol, in spite of the cellular response which was lowly suppressed in long term. The last agent was Amikacin. The humoral response was suppressed in long term. Delayed hypersensitivity of cellular response was fifthy percently suppressed. Although it is hard to state the immune response totally, either humo ral or cellular, because the matter is not known completely and the data are not satisfying, this is a fact that any drug which is highly taken to the organi- sim, will effect the immune system. So it is important not to use any anti microbial agent or other therapeutics by chance.

Benzer Tezler

  1. Pediatri kliniği servislerinde yatan ve gram-negatif çomak bakteriyemisi olan hastaların klinik ve epidemiolojik değerlendirilmesi

    The clinical and epidemiological evaluation of the patients who have gram-negative bacteremia hospitalized in pediatric clinics.

    BAHAR ÇALIŞKAN

    Tıpta Uzmanlık

    Türkçe

    Türkçe

    2012

    Çocuk Sağlığı ve Hastalıklarıİstanbul Üniversitesi

    Çocuk Sağlığı Bölümü

    PROF. DR. NURAN SALMAN

  2. Sefalosporinlere karşı allerjik reaksiyon öyküsü veren çocuklarda sefalosporin ve penisilin duyarlılığı

    Cephalosporin and penicillin sensitivity in children with a history of allergic reactions to cephalosporins

    NURŞAH EKER

    Tıpta Uzmanlık

    Türkçe

    Türkçe

    2010

    Çocuk Sağlığı ve HastalıklarıSağlık Bakanlığı

    Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı

    PROF. DR. FEYZULLAH ÇETİNKAYA

  3. Gebe olmayan izole sığır uterus kontraksiyonları üzerine Ceftiofur ve Meloxicam'ın etkileri

    Effects of Ceftiofur and Meloxicam on conctractions of uterine isolated from non-pregnant cows

    NEVZAT SAAT

    Doktora

    Türkçe

    Türkçe

    2009

    FizyolojiFırat Üniversitesi

    Doğum ve Jinekoloji (Veterinerlik) Ana Bilim Dalı

    PROF. DR. HALİS ÖCAL

  4. Sefpodoksim proksetil nanopartiküllerinin hazırlanması, fizikokimyasal özellikleri ve standardizasyonu

    Preparatıon of cefpodoxıme proxetıl nanopartıcles, physıcochemıcal propertıes and standardızatıon

    NİLÜFER ÖZKAYA

    Yüksek Lisans

    Türkçe

    Türkçe

    2010

    Eczacılık ve FarmakolojiEge Üniversitesi

    Biyofarmasötik ve Farmokokinetik Ana Bilim Dalı

    DOÇ. DR. ERCÜMENT KARASULU

  5. Deneysel alzheimer modeli oluşturulan ve serbest hareket edebilen sıçanlarda glutamat geri alınım sürelerinin ın vivo voltametri tekniği ile değerlendirilmesi

    Evaluation of glutamate re-uptake times by in vivo voltammetry technique in experimental alzheimer's modeled and freely moving rats

    CEMİL BAYRAM

    Doktora

    Türkçe

    Türkçe

    2022

    Eczacılık ve FarmakolojiAtatürk Üniversitesi

    Tıbbi Farmakoloji Ana Bilim Dalı

    PROF. DR. AHMET HACIMÜFTÜOĞLU