Synthesis of single enantiomers of ketomycolic acids
Başlık çevirisi mevcut değil.
- Tez No: 400343
- Danışmanlar: PROF. DR. MARK S. BAIRD
- Tez Türü: Doktora
- Konular: Kimya, Chemistry
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2007
- Dil: İngilizce
- Üniversite: Bangor University-Prifysgol Bangor
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Kelam ve İslam Felsefesi Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 277
Özet
Özet yok.
Özet (Çeviri)
Mycolic acids, long chain fatty acids often containing 70 to 90 carbons, are major constituents of the cell envelope of M. tuberculosis and other pathogenic mycobacteria. Their presence is thought to explain the characteristic resistance of these mycobacteria to most antibiotics and other chemotherapeutic agents.The syntheses of single enantiomers of the following mycolic acid derivatives were achieved; cis-cyclopropane keto-mycolic acid (A), ?-methyl-trans-cyclopropane keto-mycolic acid (B), cis-cyclopropane keto-meromycolaldehyde (C), ?-methyl-trans-cyclopropane keto-meromycolaldehyde (D), ?-methyl-trans-alkene keto-mycolic acid (E) and related hydroxy-mycolic acids. However, the synthesis of ??-mycolic acid (F) failed.CH3(CH2)17 (CH2)18 Me O (CH2)15 OH OH(CH2)23CH3 O CH3(CH2)17 (CH2)18 Me O (CH2)15CHO CH3(CH2)17 (CH2)17 Me O Me (CH2)15 OH OH(CH2)23CH3 O CH3(CH2)17 (CH2)17 Me O Me (CH2)15CHO AB CD CH3(CH2)17 (CH2)15 Me (CH2)17 Me O OMe OAc(CH2)21CH3 O E (CH2)17 OH OH O (CH2)21CH3 CH3(CH2)17 FThe synthesis of single enantiomers of mycolic acids will help to prove the stereochemistry of the natural ones, and tests of their biological activities may offer the development of new methods for the diagnosis and treatment of TB and related diseases.
Benzer Tezler
- Biyoteknolojik yöntemlerle kiral 4-okso-tetrahidroindol türevlerinin sentezleri
Enantioselective synthesis of 4-oxo-tetrahydroindol derivatives by using biotechnological methods
MEDİHA SÜLEYMANOĞLU ERSEZ
Yüksek Lisans
Türkçe
2011
BiyolojiYıldız Teknik ÜniversitesiBiyoloji Bölümü
YRD. DOÇ. DR. ZERRİN ZERENLER ÇALIŞKAN
- Asimetrik organik reaksiyonlar için etkili organokatalizör tasarımı
The design of effective organocatalyst for asymmetric organic reactions
MERVE KARAOĞLU
- Benzimidazol sübstitüe kiral eterlerin sentezi ve biyolojik aktivitelerinin araştırılması
Synthesis of benzimidazole substituted chiral ethers and investigation of their biological activies
MERAL BAYRAKTAR ÇAKAR
- Synthesis and reactions of thioureas, their cyclized derivatives and oxazolidindiones
Tiyoüreler, halkalaşmış türevleri ve oksazolidindionların sentezi ve reaksiyonları
ŞENEL TEKE TUNÇEL
- Organokatalizör olarak kullanılabilecek diamid yapılı bileşiklerin sentezi
Synthesis of diamide compounds as organocatalysts
ELİF KESKİN
