The effect of anti-oxidant (vitamin E and C) acting as anti-inflammatory in osteoarthritis patient treated with diclofenac sodium
Diklofenac sodyum ile tedavi edlen osteoartritli hastalarda anti-enflamatuar olarak etki eden antioksdanların (vit E ve vit C) etkisi
- Tez No: 426606
- Danışmanlar: PROF. DR. TURGAY ÇELİK
- Tez Türü: Yüksek Lisans
- Konular: Eczacılık ve Farmakoloji, Pharmacy and Pharmacology
- Anahtar Kelimeler: Antiinflamatuar ajanlar, Antioksidanlar, Askorbik asit, Diklofenak, Diklofenak sodyum, Osteoartrit, Tedavi, Vitamin E, Anti inflammatory agents, Antioxidants, Ascorbic acid, Diclofenac, Diclofenac sodium, Osteoarthritis, Treatment, Vitamin E
- Yıl: 2015
- Dil: İngilizce
- Üniversite: Yeditepe Üniversitesi
- Enstitü: Sağlık Bilimleri Enstitüsü
- Ana Bilim Dalı: Klinik Farmasi Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: Belirtilmemiş.
Özet
Özet yok.
Özet (Çeviri)
Background OA it's a common disease that occur in elderly people and it its most come in the female under age 49 than a male above 50 because of the hormonal changes and for the men for aging and other chronic disease. Objective Our objective was directed to determine the beneficial effect of the antioxidants (vitamin E and C) as anti-inflammatory in OA patients treated with diclofenac sodium. There is a reality that oxidative stress give a good progression and incidence of osteoarthritis (OA), increased production of reactive oxygen species (ROS) and decreased bioavailability of antioxidants have been checked by experimental and human OA, where increased ROS production may contribute to the elevation in OA incidence. and we use in this study different ages with OA patient to can determind the best reslu and effect we can get from this study. Patients and methods The ESR, Hgb, and serum (CRP, RF, MDA, and GSH) level were measured for each patient before treatment (at the baseline) and after 3, 5, 7, and 8 weeks of the treatment with documentation of symptoms and pain score before and after treatment (the treatment were continue for 2 months). Results There was significant (p 0.05) elevation in serum MDA level and significant reduction in serum GSH level in OA patients as compared to the healthy control subjects. The addition of vitamin E to diclofenac sodium (group B) had resulted in a significant lowering in serum MDA level with significant elevation in serum GSH level and OA outcome score (symptoms and signs score) after 3, 5, 7, and 8 weeks of treatment, likewise the addition of vitamin C to diclofenac sodium (group C) with less positive effect than vitamin E, while the use of combined antioxidants vitamin E and C (group D) resulted in significant lowering in serum MDA level with significant elevation in serum GSH level and OA outcome score (symptoms and pain score) after 3, 5, 7, and 8 weeks of the treatment with great positive effect than the use of single antioxidant (vitamin E or C) due to synergistic effect. Conclusion The oxidative stress give a progression of OA and the addition of antioxidants (vitamin E or C) to diclofenac sodium treatment give a good lowering in MDA level, and elevation in GSH level and OA outcome score (symptoms and pain score) with improving the patients compliance but all the result that I got it gave a negative result with African races . Note. that test and that laboratory data I got it from the patient directly or from their physician after I get from them official agreement that was a proved by their physician so I got a full agreement to get a full excess for their laboratory data.
Benzer Tezler
- Effect of a diet rich in olive oil phenolics on age-related changes in mouse model of ageing and HPLC analysis of olive oil phenolics with electrochemical detector
Zeytinyağı fenoliklerince zengin diyetin yaşlanması hızlandırılmış fare modelinde yaşlanmaya bağlı değişiklikler üzerine etkisi ve zeytinyağındaki fenolik maddelerin elektrokimyasal dedektör ile HPLC analizi
BANU BAYRAM
Doktora
İngilizce
2011
Beslenme ve Diyetetikİstanbul Teknik ÜniversitesiGıda Mühendisliği Ana Bilim Dalı
DOÇ. DR. BERAAT ÖZÇELİK
PROF. DR. GERALD RİMBACH
- Rat overlerinin heterotopik transplantasyonunda overyan rezerv korunması açısından C vitamini ve sildenafil molekül etkinliklerinin karşılaştırılması
Başlık çevirisi yok
MAHMUT TOLGA AYAN
Tıpta Uzmanlık
Türkçe
2021
Kadın Hastalıkları ve DoğumMaltepe ÜniversitesiKadın Hastalıkları ve Doğum Ana Bilim Dalı
PROF. DR. AYGEN ÇELİK
- D-alfa-Tokoferol`ün düz kas hücresi üzerine olan etkisinin in vivo olarak incelenmesi ve bunun aterosklerozdaki önemi
Başlık çevirisi yok
ÖNDER ŞİRİKÇİ
- Henoch-Schönlein Purpuralı çocuklarda malondialdehid, redükte glutatyon ve antioksidan etkili vitamin düzeyleri
Levels of malonylaldehyde, reductated glutathion and vitamins which have antioxıdant effect at children with Henoch-Schonlein Purpura
HAYRETTİN TEMEL
Tıpta Uzmanlık
Türkçe
2010
Çocuk Sağlığı ve HastalıklarıYüzüncü Yıl ÜniversitesiÇocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
YRD. DOÇ. DR. CİHANGİR AKGÜN
- Yulaf unu ile üretilen ekmeklerde fenolik madde içeriği ve antioksidan aktivitesine proses etkisinin araştırılması
Effect of processing on the phenolic content and antioxidant activity of oat flour substituted breads
BERNA TOPÇU
Yüksek Lisans
Türkçe
2017
Gıda Mühendisliğiİstanbul Teknik ÜniversitesiGıda Mühendisliği Ana Bilim Dalı
YRD. DOÇ. DR. NİLÜFER DİLARA ERDİL