Study on neuronal tolerance for impulsive stretch-inducedaxonal dysfunction and disruption
Başlık çevirisi mevcut değil.
- Tez No: 607957
- Danışmanlar: PROF. DR. SHİGERU AOMURA
- Tez Türü: Doktora
- Konular: Nöroloji, Nöroşirürji, Neurology, Neurosurgery
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2017
- Dil: İngilizce
- Üniversite: Tokyo Metropolitan University
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 95
Özet
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Özet (Çeviri)
Traumatic brain injury (TBI) is a major cause of morbidity and mortality that eventually leads to diffuse axonal injury (DAI) which has the mortality rate of 42%-62%. DAI is dependent on the inertial forces from rapid head accelerations/decelerations as well as the propagation of force through the brain after impact, usually caused by traffic accidents, assaults and falls, that deform the white matter and eventually lead to DAI. The two distinct types of axonal pathology arising from DAI are the swellings that induced by the neurofilament accumulation as a result of axonal dysfunction, the damaged neurofilament structure in the axonal cytoskeleton and focal compaction and/or impaired transport due to the mechanical insult along the axons, followed by secondary axotomy, and the axonal bulbs which likely represent complete axonal disconnection, referred as axonal disruption in this study. DAI can be detected histologically by the visualization of the above mentioned morphological indications using immunohistochemical labeling of multiple proteins which accumulates in injured axons. 2 In this study, axonal injury induced by uniaxial stretch on cultured cells in order to clarify the relation between the impulsive strain, strain rate, and axonal injury thresholds and provide an experimental, cell level, biomechanics based injury criteria to the literature. Uniaxial single stretching experiments are conducted in order to understand the biomechanics of moderate and severe axonal injury. Uniaxial repetitive stretching method is proposed as a valid method to study mild axonal injury which can not be examined by conventional methods. Further, stretching experiments on directionally oriented axons are performed in order to propose an additional method in order to obtain a full undertanding on neuronal tolerance. Finally, results from experiments are summarized as tolerance data for axonal dysfunction and axonal disruption separately to explain the strain and strain rate influence on neuronal tolerance clearly. Evaluation is performed by immunohistochemical labeling, and the morphology was observed before and after stretching.
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