Geri Dön

Study on neuronal tolerance for impulsive stretch-inducedaxonal dysfunction and disruption

Başlık çevirisi mevcut değil.

PDF İndir

  1. Tez No: 607957
  2. Yazar: EVRİM KURTOĞLU
  3. Danışmanlar: PROF. DR. SHİGERU AOMURA
  4. Tez Türü: Doktora
  5. Konular: Nöroloji, Nöroşirürji, Neurology, Neurosurgery
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2017
  8. Dil: İngilizce
  9. Üniversite: Tokyo Metropolitan University
  10. Enstitü: Yurtdışı Enstitü
  11. Ana Bilim Dalı: Belirtilmemiş.
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 95

Özet

Özet yok.

Özet (Çeviri)

Traumatic brain injury (TBI) is a major cause of morbidity and mortality that eventually leads to diffuse axonal injury (DAI) which has the mortality rate of 42%-62%. DAI is dependent on the inertial forces from rapid head accelerations/decelerations as well as the propagation of force through the brain after impact, usually caused by traffic accidents, assaults and falls, that deform the white matter and eventually lead to DAI. The two distinct types of axonal pathology arising from DAI are the swellings that induced by the neurofilament accumulation as a result of axonal dysfunction, the damaged neurofilament structure in the axonal cytoskeleton and focal compaction and/or impaired transport due to the mechanical insult along the axons, followed by secondary axotomy, and the axonal bulbs which likely represent complete axonal disconnection, referred as axonal disruption in this study. DAI can be detected histologically by the visualization of the above mentioned morphological indications using immunohistochemical labeling of multiple proteins which accumulates in injured axons. 2 In this study, axonal injury induced by uniaxial stretch on cultured cells in order to clarify the relation between the impulsive strain, strain rate, and axonal injury thresholds and provide an experimental, cell level, biomechanics based injury criteria to the literature. Uniaxial single stretching experiments are conducted in order to understand the biomechanics of moderate and severe axonal injury. Uniaxial repetitive stretching method is proposed as a valid method to study mild axonal injury which can not be examined by conventional methods. Further, stretching experiments on directionally oriented axons are performed in order to propose an additional method in order to obtain a full undertanding on neuronal tolerance. Finally, results from experiments are summarized as tolerance data for axonal dysfunction and axonal disruption separately to explain the strain and strain rate influence on neuronal tolerance clearly. Evaluation is performed by immunohistochemical labeling, and the morphology was observed before and after stretching.

Benzer Tezler

  1. Tez No

    596123

    Akut uzatılmış stres ile oluşturulan deneysel post-travmatik stres bozukluğu modelinde agmatinin etkilerinin incelenmesi

    Investigating effects of agmatine on single-prolonged stress post-traumatic stress model in rats

    ÖZGE BAYRU

    Yüksek Lisans

    Türkçe

    Türkçe

    2019

    Eczacılık ve FarmakolojiMarmara Üniversitesi

    Farmakoloji Ana Bilim Dalı

    PROF. DR. FEYZA ARICIOĞLU

  2. Tez No

    493324

    Endojen opioid reseptörlerin dinamiğinin araştırılması

    Investigation of the dynamics of endogenous opioid receptors

    GÜLSENA BAYDAŞ

    Yüksek Lisans

    Türkçe

    Türkçe

    2018

    Biyolojiİstanbul Medipol Üniversitesi

    Sinir Bilimi Ana Bilim Dalı

    PROF. DR. GÜRKAN ÖZTÜRK

  3. Tez No

    452809

    Pioglitazon'un spinal kord iskemi-reperfüzyon hasarı üzerine nöroprotektif etkisinin araştırılması

    Neuroprotective effects of pioglitazone research on spinal cord ischemia-reperfusion injury

    MEHMET FATİH ALPAY

    Tıpta Uzmanlık

    Türkçe

    Türkçe

    2012

    Göğüs Kalp ve Damar CerrahisiFatih Üniversitesi

    Kalp ve Damar Cerrahisi Ana Bilim Dalı

    PROF. DR. ÖMER ÇAKIR

    YRD. DOÇ. DR. NECMETTİN ÇOLAK

  4. Tez No

    464076

    Kronik obstruktif akciğer hastalığı ( KOAH) hastalarında kronik noninvaziv mekanik ventilasyonun kognitif fonksiyonlar üzerine etkisi

    The effect of chroni̇c noni̇nvasi̇ve mechani̇cal venti̇lati̇on on cogni̇ti̇ve functi̇ons i̇n copd pati̇ents

    ESRA YAVUZ TAŞPINAR

    Tıpta Uzmanlık

    Türkçe

    Türkçe

    2017

    Göğüs HastalıklarıSelçuk Üniversitesi

    Göğüs Hastalıkları Ana Bilim Dalı

    DOÇ. DR. BAYKAL TÜLEK

  5. Tez No

    814735

    Deneysel karotis arter okluzyonu oluşturulan sıçanlarda, uzak iskemik ön koşullandırmanın nöroprotektif etkinliğinin araştırılması

    Investigation of the neuroprotective effect of remote ischemic preconditioning in rats with experimental carotid artery occlusion

    FATİH ÖZDEMİR

    Tıpta Uzmanlık

    Türkçe

    Türkçe

    2013

    Göğüs Kalp ve Damar CerrahisiSağlık Bakanlığı

    Kalp ve Damar Cerrahisi Ana Bilim Dalı

    PROF. DR. ABDULLAH KEMAL TUYGUN

Geri Dön