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In vivo electrophysiological recordingsfrom neocortex via low-cost, home-madeECoG electrodes

Başlık çevirisi mevcut değil.

  1. Tez No: 707205
  2. Yazar: TANSEL BARAN YAŞAR
  3. Danışmanlar: PROF. DR. MEHMET FATİH YANIK
  4. Tez Türü: Yüksek Lisans
  5. Konular: Bilim ve Teknoloji, Elektrik ve Elektronik Mühendisliği, Science and Technology, Electrical and Electronics Engineering
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2017
  8. Dil: İngilizce
  9. Üniversite: Washington University in St. Louis
  10. Enstitü: Yurtdışı Enstitü
  11. Ana Bilim Dalı: Belirtilmemiş.
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 72

Özet

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Özet (Çeviri)

Methods of electrical recording have an important role in the readout of brain activity due to their unparalleled temporal resolution. Different electrical recording methods exist with varying levels of invasiveness. Among the existing methods, the most invasive ones which are very disruptive to the brain tissue such as implantation of electrode shanks into the brain tissue yield the most direct information from cells in the form of action potentials. On the other hand, the least invasive ones such as electroencephalography can capture only largely attenuated signals that are spatial averages of the activities of possibly hundreds of thousands of neurons in the brain. In order to address this dichotomy, recording of the action potentials from the surface of the brain have been gaining more popularity in the recent years. In this study, we aimed to record action potentials from the superficial layers of rat neocortex by using recording probes that are manufactured and processed in-house at very low costs. In our recordings from the barrel and motor cortices of anesthetized rats, we observed high-frequency waveforms that had plausible waveforms and time scales for extracellular action potential waveforms. The firing patterns of these putative single- and multi-units did not respond to different anesthesia levels whereas in some cases we observed response which was time-locked to whisker stimulation. I also worked on methodology for treating the surfaces of these electrodes for higher quality recordings and producing arrays of these low-cost electrodes in flexible substrates such as PDMS, which can lead to helpful devices in the near future. While the project fulfilled its goal of giving us confidence in the claims in literature for recording action potentials from the brain surface, recordings from awake animals via micromachined electrode arrays and secondary modalities such as optical manipulation would be necessary for the verification and further characterization of these signals, which is my currently ongoing work on this project.

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