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A simulation-based study ofBBB-on-a-chip Permeability Tuningby Induced Electric Field

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  1. Tez No: 718364
  2. Yazar: SAMET AYTEKİN
  3. Danışmanlar: PROF. JOSEP SAMİTİER MARTİ, DR. MONİCA MİR, PROF. JEROEN LAMMERTYN
  4. Tez Türü: Yüksek Lisans
  5. Konular: Elektrik ve Elektronik Mühendisliği, Electrical and Electronics Engineering
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2022
  8. Dil: İngilizce
  9. Üniversite: Katholieke Universiteit Leuven (Catholic University of Leuven)
  10. Enstitü: Yurtdışı Enstitü
  11. Ana Bilim Dalı: Belirtilmemiş.
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 76

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Özet (Çeviri)

Blood Brain Barrier (BBB) is one of the main constituents of the central nervous system that differs from non-brain endothelial vessels by its strictly controlled integrity and selective permeability. The loss of BBB integrity has been found to be related to the major neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and multiple sclerosis. In order to understand the underlying molecular mechanisms of these diseases, to develop new treatments and to test possible drug candidates, it is an urgent need to develop a platform that allows the easy tuning of the permeability of the endothelial layer. BBB-on-achip is a microfluidic device that is of increasing interest in the last decade and studies focus on the achievement of most physiologically relevant permeability of the endothelial cell layer. The use of pulsed electric field (PEF) for the BBB permeability tuning grants significant advantages over the previously tested methods; parameters of the electric field such as the amplitude, frequency, pulse duration and pulse number can easily be changed during the experiment, the application can be automatized and programmed, electric field can be applied to entire cell layer or it can be focused on specific regions and most importantly, paracellular and transcellular permeability can be induced separately. In this thesis, the possible effects of the induced electric field were investigated by the Finite Element Method (FEM)-based simulations. Two main configurations of BBB-on-a-chip, namely single-layer and multilayer chip, were modelled as 3D-constructs and the distribution of the potential, electric field and current density were simulated for different frequencies. Possibility of paracellular and/or transcellular permeabilization were discussed for different frequency regions. Accordingly, multi-layer chip configuration was found to have several major disadvantages for the use of electric field for permeabilization purposes.

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