İki farklı prenatal down sendromu tarama testinin karşılaştırılması
The comperation of two different prenatal down syndrome screening test
- Tez No: 118853
- Danışmanlar: Belirtilmemiş.
- Tez Türü: Tıpta Uzmanlık
- Konular: Tıbbi Biyoloji, Genetik, Medical Biology, Genetics
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2002
- Dil: Türkçe
- Üniversite: İstanbul Üniversitesi
- Enstitü: Cerrahpaşa Tıp Fakültesi
- Ana Bilim Dalı: Genetik Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: Belirtilmemiş.
Özet
Özet yok.
Özet (Çeviri)
VI- SUMMARY Down's syndrome is the most common chromosomal anomalies and the most common cause of mental retardation. The parameters most widely used in second trimester screening of Down's syndrome are Maternal serum Alfa-fetoprotein (MSAFP), Maternal serum human corionic gonadotropin (MS0-HCG), and Maternal serum unconjugated estriol (MsuE3). Inhibin-A (IA) has taken its place as a new parameter in the Down's syndrome screening tests performed in the second trimester of pregnancy. Every laboratory and department needs reliable values in order to use the above mentioned parameters in second trimester Down's syndrome screening tests reliably. In this study, the objective is to obtain the median values of MSAFP, MS p-HCG, MsuE3 and Maternal serum IA for each gestation week by measuring the quantities of these parameters in normal pregnant woman with confirmed healthy infant delivery throughout the 16.-18. gestation weeks in order to make screening of pregnants with Down's syndrome more accurate. We have also compared the risk of Down's syndrome obtained by the results of two different tests -one with markers MSAFP, MSp-HCG, MsuE3 and the other with markers MSAFP, MSp- HCG,MSIA- performed with 179 objects using the PRISCA Down's syndrome risk program version 3.4.22. 51The mean multiple of the median (MoM) in 50. percentile of the subjects in our study are similar to the MoM values in 50. percentile of former studies except MSAFP, whose MoM values are lower for all percentiles. A meaningful difference could not be obtained from the comparison of the risk of Down's syndrome results of two different triple tests. For this reason, we strongly recommend that the pregnancy information of the pregnant women coming to our department be obtained carefully and it should be followed whether or not a healthy infant was born. More reliable triple test results could be obtained with the median values provided by these observations. This situation can prevent the pregnant women from unnecessary invasive tests and minimize the possible complications in fetus due to these observations. 52
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