Allerjik rinitli çocuklarda serum antioksidan vitamin ve magnezyum düzeyleri
Başlık çevirisi mevcut değil.
- Tez No: 171814
- Danışmanlar: DOÇ.DR. RECEP SANCAK
- Tez Türü: Tıpta Uzmanlık
- Konular: Çocuk Sağlığı ve Hastalıkları, Child Health and Diseases
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2006
- Dil: Türkçe
- Üniversite: Ondokuz Mayıs Üniversitesi
- Enstitü: Tıp Fakültesi
- Ana Bilim Dalı: Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 84
Özet
ABSTRACT Allergic rhinitis (AR) is a inflammatory disease of nose mucous membrane, which is developing via IgE. During the inflammation, seen in allergic diseases, reactive oxygen metabolites (ROMs) are produced by several cells. These toxic metabolites cause damages in epithelial cells, which act as a block to allergens, by creating oxidative stress, and these cells are peeled off as a result. The epithelial damage and ciliary dysfunction, which appear due to the oxidative process, result in the deterioration of the symptoms and extension of treatment duration. There are different antioxidant defense systems, which are used for blocking or limiting the oxidative damage caused by ROMs in the cells and tissues, in the body. In the oxidative damaging process; a decrease in serum levels appear, related to consumption of A, E and C vitamins, which have antioxidant characteristics. Although AR is a widely seen disease among children in whole world, there are only a few studies examining the relation in between antioxidants and AR. In the literature, most of the studies, examining the relations in between allergic diseases and antioxidant vitamins, were conducted with patients who had asthma or rhinosinusitis. In some of the studies, conducted with asthma or AR patients, serum antioxidant vitamin levels were found low and it was stated that there were an inverse correlation between antioxidant vitamins and prevalence of the disease. However, there are also studies that stating no relation between allergic diseases and antioxidant vitamins. In this thesis work; examination of serum antioxidant vitamin, magnesium, iron, ferritin, total protein, albumin and lipid levels together with hemogram parameters and investigation of the risk factors, which can be effective on AR development, is intended during the first attack of the patients, who has moderate persistent AR diagnosis. The study has been conducted between January 2005 - June 2006, in Division of Allergy, Department of Children Health and Diseases, Ondokuz Mayıs University Faculty of Medicine. Thirty-five patients, at ages 73-198 (133,20 ± 41,36) months, which were diagnosed, according to their story and physical examination, as moderate persistent AR, and also were found sensitive to dust mites, according to skin prick-test; and 35 children, at ages 71-198 (147,54 ± 37,78) months, healthy, sex compatible and having normal physical examination findings, has been included in this study. Data, related to study groups, such as anthropometrical measurements, age, sex, their XIIhometown, risk factors (affecting possibly the AR development) and various social and demographical characteristics have been recorded. A“nasal symptoms scoring”has been performed to the children in patient group, and the results have been recorded. A work on serum vitamin A, E, C, magnesium, iron, ferritin, total protein, albumin and lipid levels and complete blood counts, on the venous blood samples, which were taken from study groups before breakfast, has been conducted. It has been seen that the number of children having an atopic disease history within their parents in AR group was greater in comparison to the control group. There was a statistically meaningful difference between two groups (p < 0.05). Education levels of the fathers of the children having AR were high with a statistically significant in comparison to the control group (p < 0.05). No statistically significant difference was found in the distribution of risk factors, such as education level of mothers of both patient and control groups, mother and father occupations, weight at birth, breast feeding period, active smoking in pregnancy, exposure to cigarette-smoke in pregnancy, nearby smoking at home, number of siblings, birth order, number of family members sleeping in the same room, heating system of the house and number of rooms, that can be effective on the development of AR (p > 0.05). There were statistically significant decrease in serum mean vitamin A and total cholesterol levels of the children having AR, in comparison to the control group (p < 0.05). There were no statistically significant difference in serum mean vitamin E, magnesium, triglyceride and LDL levels in the patient group, although they were lower, in comparison to the control group (p > 0.05). No statistically meaningful difference was found between patient and control groups in other biochemical parameters and complete blood count values in the study groups (p > 0.05). The results, which were found related to antioxidant vitamins, lipids and other parameters, that we have examined, contribute to our existing knowledge and to the literature, which is insufficient in this subject. In conclusion; we thought that antioxidant vitamin support, given controlled by clinical findings, will be beneficial in addition to present treatments, considering especially the pathogenesis of the AR, which has no exact treatment at present. Keywords; Allergic rhinitis, atopy, vitamin A, vitamin E, vitamin C, free radicals, magnesium XIII
Özet (Çeviri)
ABSTRACT Allergic rhinitis (AR) is a inflammatory disease of nose mucous membrane, which is developing via IgE. During the inflammation, seen in allergic diseases, reactive oxygen metabolites (ROMs) are produced by several cells. These toxic metabolites cause damages in epithelial cells, which act as a block to allergens, by creating oxidative stress, and these cells are peeled off as a result. The epithelial damage and ciliary dysfunction, which appear due to the oxidative process, result in the deterioration of the symptoms and extension of treatment duration. There are different antioxidant defense systems, which are used for blocking or limiting the oxidative damage caused by ROMs in the cells and tissues, in the body. In the oxidative damaging process; a decrease in serum levels appear, related to consumption of A, E and C vitamins, which have antioxidant characteristics. Although AR is a widely seen disease among children in whole world, there are only a few studies examining the relation in between antioxidants and AR. In the literature, most of the studies, examining the relations in between allergic diseases and antioxidant vitamins, were conducted with patients who had asthma or rhinosinusitis. In some of the studies, conducted with asthma or AR patients, serum antioxidant vitamin levels were found low and it was stated that there were an inverse correlation between antioxidant vitamins and prevalence of the disease. However, there are also studies that stating no relation between allergic diseases and antioxidant vitamins. In this thesis work; examination of serum antioxidant vitamin, magnesium, iron, ferritin, total protein, albumin and lipid levels together with hemogram parameters and investigation of the risk factors, which can be effective on AR development, is intended during the first attack of the patients, who has moderate persistent AR diagnosis. The study has been conducted between January 2005 - June 2006, in Division of Allergy, Department of Children Health and Diseases, Ondokuz Mayıs University Faculty of Medicine. Thirty-five patients, at ages 73-198 (133,20 ± 41,36) months, which were diagnosed, according to their story and physical examination, as moderate persistent AR, and also were found sensitive to dust mites, according to skin prick-test; and 35 children, at ages 71-198 (147,54 ± 37,78) months, healthy, sex compatible and having normal physical examination findings, has been included in this study. Data, related to study groups, such as anthropometrical measurements, age, sex, their XIIhometown, risk factors (affecting possibly the AR development) and various social and demographical characteristics have been recorded. A“nasal symptoms scoring”has been performed to the children in patient group, and the results have been recorded. A work on serum vitamin A, E, C, magnesium, iron, ferritin, total protein, albumin and lipid levels and complete blood counts, on the venous blood samples, which were taken from study groups before breakfast, has been conducted. It has been seen that the number of children having an atopic disease history within their parents in AR group was greater in comparison to the control group. There was a statistically meaningful difference between two groups (p < 0.05). Education levels of the fathers of the children having AR were high with a statistically significant in comparison to the control group (p < 0.05). No statistically significant difference was found in the distribution of risk factors, such as education level of mothers of both patient and control groups, mother and father occupations, weight at birth, breast feeding period, active smoking in pregnancy, exposure to cigarette-smoke in pregnancy, nearby smoking at home, number of siblings, birth order, number of family members sleeping in the same room, heating system of the house and number of rooms, that can be effective on the development of AR (p > 0.05). There were statistically significant decrease in serum mean vitamin A and total cholesterol levels of the children having AR, in comparison to the control group (p < 0.05). There were no statistically significant difference in serum mean vitamin E, magnesium, triglyceride and LDL levels in the patient group, although they were lower, in comparison to the control group (p > 0.05). No statistically meaningful difference was found between patient and control groups in other biochemical parameters and complete blood count values in the study groups (p > 0.05). The results, which were found related to antioxidant vitamins, lipids and other parameters, that we have examined, contribute to our existing knowledge and to the literature, which is insufficient in this subject. In conclusion; we thought that antioxidant vitamin support, given controlled by clinical findings, will be beneficial in addition to present treatments, considering especially the pathogenesis of the AR, which has no exact treatment at present. Keywords; Allergic rhinitis, atopy, vitamin A, vitamin E, vitamin C, free radicals, magnesium XIII
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