Geri Dön

X-Kromozomal STR Polimorfizmi (DXS8377, DXS101X DXS6789, STR-1, HUMHPRTB) ve Türk Toplumundaki Alel Freskansları

X-Chromosomal STR pOLYMORPHİSM (DXS8377, DXS101X DXS6789, STR-1, HUMHPRTB) and Turkish Allele Frequencies

PDF İndir

  1. Tez No: 192908
  2. Yazar: FARUK AŞICIOĞLU
  3. Danışmanlar: PROF.DR. MAHMUT N. ÇARİN
  4. Tez Türü: Doktora
  5. Konular: Tıbbi Biyoloji, Medical Biology
  6. Anahtar Kelimeler: X-STRs, gonosomal STRs, paternity testing, kinship analysis, forensicgenetics
  7. Yıl: 2006
  8. Dil: Türkçe
  9. Üniversite: İstanbul Üniversitesi
  10. Enstitü: Sağlık Bilimleri Enstitüsü
  11. Ana Bilim Dalı: Tıbbi Biyoloji Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 99

Özet

ÖZET$úÕFÕR÷OX ) ;.URPR]RPDO 675 3ROLPRUIL]PL ';6 ';6';6 675; +80+357% YH 7UN 7RSOXPXQGDNL $OHO )UHNDQVODUÕ øVWDQEXOhQLYHUVLWHVL 6D÷OÕN %LOLPOHUL (QVWLWV 7ÕEEL %L\RORML $QDELOLP 'DOÕ 'RNWRUD 7H]LøVWDQEXOùLPGL\H NDGDU oRN VD\ÕGD RWR]RPDO '1$ SROLPRUIL]PL DGOL DPDoOÕ RODUDNGH÷HUOHQGLULOPLú JHUHN EL\RORMLN |UQHNOHULQ JHUHNVH DNUDEDOÕN LOLúNLOHULQLQVDSWDQPDVÕQGD \D\JÕQ NXOODQÕP DODQÕ EXOPXúWXU 6RQ \ÕOODUGD DGOL JHQHWLN LQFHOHPHOHUDUWDQ ELU úHNLOGH

Özet (Çeviri)

ABSTRACT$úÕFÕR÷OX ) X-Chromosomal STR Polymorphism (DXS8377, DXS101,DXS6789, STRX-1, HUMHPRTB) and Turkish Allele Frequencies, Institute of Health6FLHQFH0HGLFDO%LRORJ\3K'7KHVLVøVWDQEXOA large number of autosomal DNA polymorphisms have been evaluated forforensic use and widely applied to stain analysis and kinship testing. In addition,forensic interest has increasingly focused on Y-chromosomal markers over the past fewyears. So far, X linked STRs have received little attention in forensic literature. The aimof this study is to determine the allele frequencies of five X-chromosomal STR loci, andto evaluate their efficiency in forensic practice. DNA was extracted from the blood ofunrelated Turkish citizens (126 females, 139 males) using 5% Chelex 100. PCRamplification was performed using fluorecently labeled primers for DXS8377, DXS101,DXS6789, STRX-1, HUMHPRTB loci, sequenced based on gene bank information.The PCR touch down protocol was chosen. The PCR products were analysed bycapillary electrophoresis by ABI Prism 310. DXS8377 and DXS101 loci have both 18alleles following by DXS1(11 alleles), DXS6789(10)alleles, and HPRTB(8 alleles),respectively. DXS8377 and DXS101 loci have both very high, PIC, MEC and PDvalues, respectively. In contrast, DXS6789 has the lowest values from this aspect.PD(female) values are higher than PD(male) values at all loci. The allele frequencies inthis study showed very similar distributions with some population such as German,$XVWULDQ 6SDQLVK øWDOLDQ DQG 3ROLVK ;FKURPRVRPH 675V DUH KLJKO\ LQIRUPDWLYHmarkers for kinship testing and especially important in deficiency cases, because themean exclusion chance of X-STRs tends to be higher than that of autosomal STR loci.

Benzer Tezler

  1. Tez No

    247769

    X kromozomuna bağlı 8 STR lokusunun polimorfizmi ve adli bilimlerdeki önemi

    Polymorphism and importance in forensic sciences of eight X-STRs loci

    ERHAN AÇAR

    Yüksek Lisans

    Türkçe

    Türkçe

    2009

    Adli Tıpİstanbul Üniversitesi

    Fen Bilimleri Ana Bilim Dalı

    YRD. DOÇ. DR. GÖNÜL FİLOĞLU

  2. Tez No

    443963

    Türkiye'de X kromozomuna bağlı 12 STR lokusunun genetik analizi

    Genetic analysis of 12STR loci chromosome X-linked in Turkey

    ARZU EROĞLU

    Doktora

    Türkçe

    Türkçe

    2016

    Adli TıpAnkara Üniversitesi

    Disiplinlerarası Adli Bilimler Ana Bilim Dalı

    PROF. DR. BERRİN İMGE ERGÜDER

  3. Tez No

    377009

    X kromozomu üzerinde bulunan 15 SNP lokusunun Türkiye toplumundaki polimorfizmi

    Polymorphism of the 15 snps loci on the X chromosome in Turkey population

    İLKSEN TAVACI

    Yüksek Lisans

    Türkçe

    Türkçe

    2014

    Adli Tıpİstanbul Üniversitesi

    Fen Bilimleri Ana Bilim Dalı

    YRD. DOÇ. DR. HAVVA ALTUNÇUL

  4. Tez No

    611666

    X kromozomu üzerinde bulunan ındel lokuslarına ait multipleks panel geliştirilmesi

    Development of an x-chromosome indel multiplex panel

    ZÜLAL SEVAL USLU

    Yüksek Lisans

    Türkçe

    Türkçe

    2019

    Adli Tıpİstanbul Üniversitesi-Cerrahpaşa

    Fen Bilimleri Ana Bilim Dalı

    DR. ÖĞR. ÜYESİ GÖNÜL FİLOĞLU TÜFEK

  5. Tez No

    478817

    Gonozomal ındel lokuslarına ait multipleks kit geliştirilmesi

    Gonozomal indel lokuslarina ait multipleks kit geliştirilmesi

    TUĞBA ÜNSAL

    Doktora

    Türkçe

    Türkçe

    2016

    Adli Tıpİstanbul Üniversitesi

    Fen Bilimleri Ana Bilim Dalı

    YRD. DOÇ. DR. GÖNÜL FİLOĞLU TÜFEK

Geri Dön