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Uzun süreli sigara kullanımının sistemik ve renal vasküler fonksiyonlara etkisi

The effect of long term cigarette smoking on sistemic and renal vascular functions

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  1. Tez No: 297442
  2. Yazar: HASAN ÇAKIR
  3. Danışmanlar: PROF. DR. SANİYE ŞEN
  4. Tez Türü: Tıpta Uzmanlık
  5. Konular: Nefroloji, Nephrology
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2011
  8. Dil: Türkçe
  9. Üniversite: Trakya Üniversitesi
  10. Enstitü: Tıp Fakültesi
  11. Ana Bilim Dalı: İç Hastalıkları Ana Bilim Dalı
  12. Bilim Dalı: Nefroloji Bilim Dalı
  13. Sayfa Sayısı: 96

Özet

Kardiyovasküler hastalıklarda birçok risk faktörünün bir arada oluşu, tek başına sigaraya bağlı riskin ortaya konmasını güçleştirmiştir. Çalışmamızda tanımlanmış hastalığı olmayan, ilaç kullanmayan, sağlıklı 40 sigara içmeyen ve 118 sigara içen bireyde sigara içim süre ve yoğunluğunun erken sistemik ve renal vasküler hasar göstergelerine etkisinin araştırılması amaçlandı. Yaş, kilo, bel çevresi, kan basınçları kontrol grubuna benzer, sigara içen grupta kontrol grubuna göre vücut kitle indeksi, açlık kan şekeri değerleri anlamlı düşük, hemoglobin, hematokrit, lökosit, ortalama eritrosit hacmi, fibrinojen, glomerül filtrasyon hızı değerleri anlamlı yüksek bulunarak (p

Özet (Çeviri)

In cardiovascular diseases, many risk factors? taking place altogether has made the risk related to smoking to be put forth difficult. In this study, the effect of the duration and intensity of smoking to early systemic and renal vascular damage markers for 40 nonsmoker and 118 smokers whom have no characterized disease and are under no medical care has been aimed.As the ages, weights, waist perimeters and blood pressures similar to the control group, in the smokers group, the body mass index (0.046) and the fasting blood glucose (0.023) values have been determined to be significantly low, and the hemoglobin (0.0025), hematocrit (0.0001), leukocyte (0.0338), mean erytrocyte volume (0.007), fibrinogen (0.040), glomerular filtration rate (0.0003) values have been determined to be significantly high compared with the control group; as a result it has been observed that smoking has caused systemic and renal vascular damage with the metabolic, inflammatory and hematological mechanisms. Systemic and renal vascular damage markers according to the short-term, medium-term and long-term smoking have been compared by separating the smoking group into three groups according to the number of cigarettes smoked daily, number of years of smoking and the number of packages smoked/year. Among the group according to the number of years of smoking, the age (0.000), diastolic blood pressure (0.003), glomerular filtration rate (0.005), fibrinogen (0.007), leukocyte (0.042), hemoglobin (0.011), mean kerytrocyte volume (0.007) values have increased, and according to the number of packages smoked/year, systolic blood pressure (0.014), diastolic blood pressure (0.020), glomerular filtration rate values (0.017), leukocyte (0.012), hemoglobin (0.011), c-reactive protein (0.009), fibrinogen (0.017), the rate of urinary albumin excretion to urinary creatinine (0.006) have been determined to be significantly high, and the fasting blood glucose (0.002), total cholesterol (0.017) have been found to be low. It has been determined that as the number of cigarettes smoked daily increased, also the hemoglobin (0.003), mean erytrocyte volume (0.008), the rate of urinary endotelin to urinary creatinine (0.013), p-selectin (0.023) values have increased. A significant positive linear relation has been determined between the number of years of smoking and the values of fibrinogen (r = 0.223, p = 0.004), c-reactive protein (r = 0.244, p = 0.008), triglyceride (r = 0.223, p = 0.015), and the fasting blood glucose (r = 0.222, p = 0.016); and a significant negative linear relation has been found again between the number of years of smoking and the value of albumin (r = -0.436, p = 0.000). A significant positive linear relation has been determined between the number of cigarettes smoked daily and the rate of urinary endotelin to urinary creatinine (r = 0.230, p = 0.013) and also the rate of urinary albumin excretion to urinary creatinine (r = 0.213, p = 0.021). A positive linear relation between the number of packages smoked/year and the age (r = 0.639, p= 0.021), serum c-reactive protein (r = 0.258, p = 0.005), fasting blood glucose (r = 0.244, p = 0.008), total cholesterol (r = 0.202, p = 0.028), triglyceride (r = 0.198, p = 0.031), plasma fibrinogen (r = 0.186, p = 0.044) have been obtained, on the other hand, a significant negative linear relation between the number of packages smoked/year and the serum albumin (r = -0.327, p = 0.000) has been determined.The results we obtained showed that smoking has damaged systemic and vascular functions for the young men with no health problem or adherent cardiovascular risk factors; and as a result of medium and long-term smoking, renal vascular influence has become clear.Key words : Cigarette, oxidative stress, atherosclerosis, renal disfunction

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