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Diabetes mellitus'lu hastalarda glikozillenmiş hemoglobin ve karbonik anhidraz miktarlarının tespiti

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  1. Tez No: 354990
  2. Yazar: ALİ YILDIRIM
  3. Danışmanlar: PROF. DR. E. EDİP KEHA
  4. Tez Türü: Yüksek Lisans
  5. Konular: Kimya, Chemistry
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 1989
  8. Dil: Türkçe
  9. Üniversite: Atatürk Üniversitesi
  10. Enstitü: Fen Bilimleri Enstitüsü
  11. Ana Bilim Dalı: Kimya Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 42

Özet

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Özet (Çeviri)

In this study, glycosylated carbonic anhydrase values in carbonic anhydrase solution purified by affinity chromatography and glycosylated hemoglobin values were determined for 10 healty control subjects (10 males, 22-30 yr of age) and 10 patients with diabetis mellitus (8 femilles and 2 males, 20-40 yr of age) . Determinations of glycosylated hemoglobin and glycosylated carbonic anhydrase were carried out by the colorimetric method developed by Parker and co-workers. The amount of hemoglobin in the hemolized and the amount of protein in the purified enzyme solution were determined by cyanmethemoglobin method and by coomassie-blue method respectively. While the glycosylated hemoglobin value was found 0,80 ± O,lll;'mol fructose/gr.Hb (mean ± SD).10 -4 Glycosylated carbonic anhydrase value was 3,03.10 +_Ll 0,53.10 . mg. glucose/mg. protein.in the control group, these values were 2,29 ± 0,90 pmol fructose/gr. Hb. and 6,38.10 - ± 0,53.10 -4 mg. glucose/mg. protein (mean + SD) in diabetic group respectively. The results of statistical analyse showed that the difference between glycosylated hemoglobin and glycosylated carbonic anhydrase values for diabetic and control'groups was important (for both PZO,OOl). I'lhile there was less important correlation betvleen glycosylated hemoglobin and glycosylated carbonic anhydrase (r= -0,64, P~0,05) for the control group, there was no correlation between these values for the diabetic group (r= 0,49, P > 0, 05) •

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