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pH dependence of histamine modulation on NMDA response in hippocampal slices

Başlık çevirisi mevcut değil.

  1. Tez No: 364501
  2. Yazar: HALE SAYBAŞILI
  3. Danışmanlar: PROF. DR. YUSUF P. TAN, PROF. DR. HELMUT L. HAAS
  4. Tez Türü: Doktora
  5. Konular: Biyoteknoloji, Biotechnology
  6. Anahtar Kelimeler: Histamine modulation, NMDA receptors, Patch-clamp technique
  7. Yıl: 1995
  8. Dil: İngilizce
  9. Üniversite: Boğaziçi Üniversitesi
  10. Enstitü: Biyo-Medikal Mühendislik Enstitüsü
  11. Ana Bilim Dalı: Biyoteknoloji Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 97

Özet

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Özet (Çeviri)

The histaminergic system in the brain emanates from the tuberomammilary nucleus of the posterior hypothalamus and projects to the whole central nervous system. In this research, the effect of histamine was investigated in the CAl region of the hippocampus of rats in vitro. The enhancement of activity mediated by classical histamine receptors has been confirmed and a new independent action of histamine on N-Methyl D-Aspartatic acid (NMDA) receptors has been described in, 1. hippocampal slices as an epileptiform field activity in magnesium free medium, representing NMDA receptor mediated extracellular activity , 2. thin hippocampal slices with patch-clamp technique as an effect on the NMDA components of excitatory postsynaptic currents. The extracellular activity evoked by the stimulation of Schaffer collateralcommisural pathway was recorded from CA I stratum pyramidale and stratum radiatum The NMDA components of excitatory currents evoked by glutamate in the CAl region of rat hippocampal slices and their modification by histamine were investigated by using the patch-clamp tight seal whole cell recording technique. In this study it has been found that histamine has no influence on non-NMDA current but effects the NMDA current in a pH dependent way. Histamine potentiates the NMDA current at pH 7.2 while it depresses the current at pH 7.6. The NMDA current modification by histamine was not mediated by the activation of known histamine receptors of HI, H2 or H3 type. The effect resembles the known interaction of polyamines with the NMDA receptorionophore complex. This work is consistent with the concentration clamp experiments in isolated hippocampal pyramidal cells and emphasizes the physiological and pathophysiological implications: Slight shifts in pH as shown here to profoundly influence the histamine action occur locally during intense nervous activity, tetanic stimulation and globally during anoxia. The modulating action of the histaminergic system in the brain will be specifically targetted towards plasticity under these conditions.

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