Geri Dön

Characterisation studies of novel block copolymer assemblies

Başlık çevirisi mevcut değil.

PDF İndir

  1. Tez No: 400939
  2. Yazar: GÖKÇEN YAŞAYAN
  3. Danışmanlar: PROF. CAMERON ALEXANDER, DR. STEPHANIE ALLEN, PROF. MARTYN DAVIES
  4. Tez Türü: Doktora
  5. Konular: Eczacılık ve Farmakoloji, Pharmacy and Pharmacology
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2013
  8. Dil: İngilizce
  9. Üniversite: The Unıversıty Of Nottıngham
  10. Enstitü: Yurtdışı Enstitü
  11. Ana Bilim Dalı: Belirtilmemiş.
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: Belirtilmemiş.

Özet

Özet yok.

Özet (Çeviri)

In the last decade, block copolymers have attracted growing interest because of their ability to form a wide range of nanostructures through self assembly. These nanostructures could be designed to have miscellaneous properties, such as high stability, biocompatibility, functionality, capacity of carrying a variety of molecules and versatile architectures. Block copolymers can be prepared as hybrid systems with many diverse compounds including biomolecules. Moreover, they can be environment responsive, and release of components within the polymer can be controlled by stimuli. Due to these properties, block copolymers are finding applications in several areas including drug delivery, biotechnology and diagnostics. In this thesis it was aimed to characterise a variety of novel block copolymer assemblies in order to have a better understanding about the properties of these materials for potential applications in pharmaceutical sciences. Assemblies including the block co-polymers of synthetic materials, the block co-polymers of synthetic materials and proteins, and the block co-polymers of synthetic materials and nucleic acids were characterised by AFM, and additionally by TEM, DLS, fluorescence spectrometry and zeta potential measurements. The morphologies and self-assembly mechanisms of the structures were investigated by altering the conditions (i.e. temperature, pH and buffer strength), and the real-time responses were recorded in order to be able to predict in vitro and in vivo behaviours of these systems. Also the effects of additional substances (i.e. biomolecules and reducing agents) to assembly/disassembly paths of the materials were inspected. The results of this project provide some useful and new insights about the behaviour of a range of block copolymer materials such as self-assembly properties of the synthetic block copolymer structures and the stability of these assemblies at various pH values, dynamic nature of protein-polymer conjugates across temperature changes, and response mechanisms of DNA-polymer conjugates across a number of stimuli (i.e. binding / hybridisation / strand breaking stimulus) which influence the assembly/disassembly paths of the materials. This information leads to better understanding of their potential applications as drug delivery systems, advanced responsive therapeutics, and diagnostics, and also designing better systems in future studies.

Benzer Tezler

  1. Tez No

    400431

    Synthesis, characterisation and evaluation of novel methacrylatebased water-soluble block copolymers

    Başlık çevirisi yok

    VURAL BÜTÜN

    Doktora

    İngilizce

    İngilizce

    1999

    Metalurji MühendisliğiUnıversıty Of Sussex

    Malzeme Bilimi ve Mühendisliği Ana Bilim Dalı

    STEVE ARMES

  2. Tez No

    143095

    Synthesis and characterization of novel well-defined macrophotoinitiators prepared by ATRP and ROP methods and their use in block copolymerization

    ATRP ve ROP metodları ile tasarlanmış yeni makrofotobaşlatıcıların sentezi, karakterizasyonu ve blok kopolimerizayonda kullanılmaları

    MUSTAFA DEĞİRMENCİ

    Doktora

    İngilizce

    İngilizce

    2003

    Polimer Bilim ve Teknolojisiİstanbul Teknik Üniversitesi

    Polimer Bilim ve Teknolojisi Ana Bilim Dalı

    PROF. DR. YUSUF YAĞCI

  3. Tez No

    126768

    Synthesis and characterization of well defined ABC type triblock copolymers via atom transfer and stable free radical polymerization

    Atom transfer ve kararlı serbest radikal polimerizasyonu ile iyi tanımlanmış ABC tip triblok kopolimerlerin sentezi ve karakterizasyonu

    TUBA ERDOĞAN

    Yüksek Lisans

    İngilizce

    İngilizce

    2002

    Polimer Bilim ve Teknolojisiİstanbul Teknik Üniversitesi

    Polimer Bilim ve Teknolojisi Ana Bilim Dalı

    PROF. DR. ÜMİT TUNCA

  4. Tez No

    840247

    Üçlü blok poli(etilen glikol)-b-[poli(laktit-ko-serin-nh2)] polimerlerin sentezi ve karakterizasyonu

    Synthesis and characterization of triblock poly(ethylene glycol)-b-[poly(lactide-co-serine-nh2)] polymers

    MATIN YAZDANI KOHNESHAHRI

    Doktora

    Türkçe

    Türkçe

    2023

    KimyaHacettepe Üniversitesi

    Kimya Ana Bilim Dalı

    DR. ÖĞR. ÜYESİ CENGİZ UZUN

  5. Tez No

    884188

    Biomedical application of an enzymatically synthesized biopolyester

    Enzimatik olarak sentezlenmiş bir biyopoliesterin biyomedikal uygulaması

    ŞENOL BEYAZ

    Yüksek Lisans

    İngilizce

    İngilizce

    2024

    Biyoteknolojiİstanbul Teknik Üniversitesi

    Kimya Mühendisliği Ana Bilim Dalı

    PROF. DR. FATOŞ YÜKSEL GÜVENİLİR

Geri Dön