Temperature based 3D core-shell simulation of hydrogel behavior for controlled drug delivery
Başlık çevirisi mevcut değil.
- Tez No: 401005
- Danışmanlar: DR. JINGJING JENNY QIU
- Tez Türü: Yüksek Lisans
- Konular: Makine Mühendisliği, Mechanical Engineering
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2012
- Dil: İngilizce
- Üniversite: Texas Tech Unıversıty
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: Belirtilmemiş.
Özet
Özet yok.
Özet (Çeviri)
Some protein gels are products of the dairy industry and some are also used as pH-sensitive gels for the controlled delivery of biologically active substances. To understand the dynamics of drug delivery, it is very important to establish a mathematical model of protein gel swelling. This required the identification and integration of theory and equations from a wide range of topics. The aim of this research was to develop a mathematical model of transport in polyelectrolyte gels and also modeling the swelling behavior using COMSOL. The model yielded a set of partial differential equations with algebraic equations for which COMSOL was selected as the simulation software. Although it was found that COMSOL could not always solve the model equations, numerical solutions were obtained for several cases. Satisfactory solutions could not be obtained for all cases using commercial software such as COMSOL Multi-physics. It was shown that COMSOL did not conserve mass but conservativeness was critical in this application because pH and hence the net protein charge is very sensitive to the mass of hydrogen present. In the future, further research should be carried out to investigate stomach, stomach acid and hydrogel behaviors and the interaction between these parties.
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