Roles of hssB1 and hssB2 in the DNA damage checkpoint response
Başlık çevirisi mevcut değil.
- Tez No: 403151
- Danışmanlar: Dr. AZİZİ SANCAR
- Tez Türü: Yüksek Lisans
- Konular: Biyofizik, Biyokimya, Biophysics, Biochemistry
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2009
- Dil: İngilizce
- Üniversite: University of North Carolina at Chapel Hill
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 30
Özet
Özet yok.
Özet (Çeviri)
Single strand DNA binding proteins (SSBs) play important roles in DNA replication, homologous recombination, DNA damage checkpoint and other repair mechanisms. Single-stranded DNA causes a DNA-damage checkpoint response. RPA appears to be the major SSB responsible for this signaling cascade. In addition to RPA, two more SSB proteins have been recently discovered in human cells, human SSB1 and human SSB2, found by sequence homology to an archaeal SSB. In addition to sequence homology, hSSB1 was found to bind ssDNA in vitro. DNA damage is a deleterious event in the cell because of the possibility that it may lead to mutations, cell death, or oncogenesis. My objective was to determine the roles of hSSB1 and hSSB2 in the ATR-dependent checkpoint response. In this study, the DNA-binding activities of hSSB1 and hSSB2 were tested by electrophoretic mobility shift assay (EMSA). Concurrently, the enhancement of ATR kinase activity by the two human SSBs was assessed by an in vitro kinase assay. By testing hSSB1 and hSSB2 in this assay, we have clarified the functions of these proteins, allowing us to make inferences about the in vivo roles of these proteins.
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