Asymmetric transfer hydrogenation of ketones with Ru(II) and Ir(III) phosphinite complexes
Başlık çevirisi mevcut değil.
- Tez No: 418833
- Danışmanlar: DOÇ. DR. MURAT AYDEMİR
- Tez Türü: Yüksek Lisans
- Konular: Kimya, Chemistry
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2016
- Dil: İngilizce
- Üniversite: Dicle Üniversitesi
- Enstitü: Fen Bilimleri Enstitüsü
- Ana Bilim Dalı: Kimya Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 73
Özet
Özet yok.
Özet (Çeviri)
Transition metal catalyzed homogeneous asymmetric catalysis is an important field of research, and the design and development of efficient ligands for this process have been withdrawing considerable interest. Today, a great number of chiral compounds and enantiomerically pure drugs are obtained through these reactions. It is known that the reactivity and stereoselectivity of an asymmetric conversion depend on the structure of the chiral ligand coordinated to the transition metal, thus, the design and synthesis of efficient chiral ligands are important in this field. Furthermore, transfer hydrogenation reactions are simple, environmentally benign and easy to handle and reaction conditions are not so harsh. Since the ferrocene moiety is easily modifiable and has highly electron donating property, it has been widely studied as a backbone of chiral phosphine ligand. In addition, the ferrocene derived ligands generally crystallize readily and they are relatively air stable compared to their nonferrocenyl analogous. These features are beneficial for purification and usage of the ligands. Furthermore, the unique structure of ferrocenes allows one to design a variety of chiral ferrocenyl phosphine ligands, which are useful tools in metal-catalyzed asymmetric reactions. In the present work, six precursors for alcohols were prepared, from which six different alcohols were obtained. Then, six phosphinite ligands, 1-6 were synthesized by the reaction of these compounds with Ph2PCl. Treatment of 1-4 with Ir gave Ir(III) complexes, 1a-4a, while reaction of ligands 5 and 6 with [Ru(η6-p-cymene)Cl2]2 or [Ru(η6-benzene)Cl2]2 afforded new Ru(II) complexes 5a-b and 6a-b, which were characterized by spectroscopic methods, such as NMR and IR, and elemental analysis. Finally, these complexes were employed as catalyst in transfer hydrogenation reaction of ketones. Generally, high conversions and with some complexes enantiomeric excess (ee) up to 98 % were obtained.
Benzer Tezler
- Synthesis of new phosphinite ligands and their Ru(II) complexes: Investigation of their catalytic application in the asymmetric transfer hidrogenation
Başlık çevirisi yok
JALAL ABDALLA SAEED KHOSHNAW
- Heterodonör ligand sentezi ve katalitik uygulamalarının araştırılması
Synthesis of heterodonor ligands and investigation of their catalytic applications
NERMİN MERİÇ
- Kiral katalizör olarak kinazolinon ve kinazolin'lerin rutenyum bileşikleri ortamında katalitik asimetrik transfer hidrojen reksiyonundaki etkileri
The effect of catalytic asymetric transfer hydrogenation of quinazolinone and quinazoli̇ne as chiral catalyst in the presence of ruthenium
ÖZLEM AYDEMİR
Yüksek Lisans
Türkçe
2017
KimyaOsmaniye Korkut Ata ÜniversitesiKimya Ana Bilim Dalı
PROF. DR. SABRİ ULUKANLI
- Ferrosen temelli C2-simetrik kiral fosfinit bileşikleri ve geçiş metal komplekslerinin sentezi, tanımlanması ve asimetrik transfer hidrojenasyon reaksiyonlarındaki katalitik etkinliklerinin araştırılması
Synthesis and characterization of ferrocenyl-based C2 symmetric phosphinite ligands and their transition metal complexes and investigation of their catalytic activities in asymmetric transfer hydrogenation reactions
BÜNYAMİN AK
- Bazı amino asitlerden türetilmiş kinazolin temelli rutenyum(II) komplekslerinin sentezi ve asimetrik transfer hidrojenasyon reaksiyonu ile ketonların indirgenme denemeleri
The synthesis of quinazoline based ruthenium (II) complexes deri̇ved from certain amino acids and ketones reduction testi̇ng vi̇a asymmetric transfer hydrogenation reaction
AHMET AĞAÇ
Yüksek Lisans
Türkçe
2015
KimyaKahramanmaraş Sütçü İmam ÜniversitesiKimya Ana Bilim Dalı
YRD. DOÇ. DR. ŞEMİSTAN KARABUĞA
