با کرم ( Artemisia sieberi)' مقایسه اثرات درمانی نانو اسانس گیاه 'درمنهکتوکونازول 2% در درمان خوکچههاي هندي مبتلا به درماتوفیتوز تجربی ناشی از میکروسپوروم کنیس
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- Tez No: 544202
- Danışmanlar: Dr. SIAMAK MASHHADI RAFIEE
- Tez Türü: Doktora
- Konular: Biyoloji, Botanik, Ziraat, Biology, Botany, Agriculture
- Anahtar Kelimeler: nano-essence, Artemisia sieberi, Ketoconazole, Microsporum canis, guinea- pig
- Yıl: 2018
- Dil: Farsça
- Üniversite: Daneshgahe Azad-e-Islami
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 80
Özet
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Özet (Çeviri)
Essences have well known properties. Transforming a drug to nano sized particles usually adds some additional potency to that drug. In this study we used Artemisia sieberi nano-essence to treat Microsporum canis induced dermatophytosis in guinea pig model. In vivo and In vitro methods were used to investigate the antifungal properties of nano-essence. Minimum inhibitory concentration of nano-essence was considered as 0.3% to 2% using Microdilution broth Clinical Laboratory Standards Institute (CLSI) M38-A protocol. 42 guinea pig divided to 7 groups, each group had 6 members. Treatment started 5 days after infection as 12 hours regimen until 45 days post infection. Both Ketoconazole and nano-essence groups had complete cure at day 40 and“no treatment group”did not have any cure in this period of time. Results show that this nano-essence is effective drug to treat M.canis induced dermatophytosis besides its efficacy is same as ketoconazole. At the end of study, statistical analysis was done by Mann-Whitney U-test (spss for windows).
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