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مطالعه برهمکنش نانوذرات با سلول انسانی در تراشۀ میکروفلوئیدی

Study of the Interaction of Nanoparticles with Human Cells in MicrofluidicChip

  1. Tez No: 719809
  2. Yazar: ESRA ERMİŞ
  3. Danışmanlar: DR. ZEİNAB BAGHERİ, DR. HAMİDEH EHTESABİ, PROF. DR. HAMİD LATİFİ
  4. Tez Türü: Yüksek Lisans
  5. Konular: Genetik, Biyomühendislik, Genetics, Bioengineering
  6. Anahtar Kelimeler: microfluidic chip, red carbon dots, cancer
  7. Yıl: 1983
  8. Dil: Arapça
  9. Üniversite: Shahıd Beheshtı Unıversıty
  10. Enstitü: Yurtdışı Enstitü
  11. Ana Bilim Dalı: Belirtilmemiş.
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: Belirtilmemiş.

Özet

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Özet (Çeviri)

Cancer is the leading cause of death worldwide. The complex and chaotic environment of the tumor makes it very difficult to treat. Two-dimensional cell culture is not ideal for traditional drug screening because twodimensional culture does not accurately determine the physiological conditions of tumor cells. Therefore, it is necessary to use a new cell model that is more similar to the body's cells for the purpose of drug discovery and evaluation. Spheroids are one of the most widely used models of 3D culture that are close to cancerous masses in terms of cell structure, biochemistry and genetics and can be produced in the laboratory using various methods. Among all the methods, microfluidic chips have unique advantages such as small size, possibility of precise control of liquids, reduction of consumables, which has caused them to be considered as an efficient method for spheroid production. In this study, using a 3D printer and soft lithography, a microfluidic chip with wells with a depth of 300 μm was created and it was used as a substrate to study the toxicity of a group of nanomaterials called carbon dot. The carbon dot synthesis used in this study is considered as the second part of this project. The excitation and emission wavelengths of synthesized carbon dot are 456 and 584 nm, respectively, which can be used for bioimaging applications due to its red emission. Visible-ultraviolet absorption spectroscopy, spectrofluorimetry, FTIR, DLS and AFM were used to characterize this carbon dot. The results of MTT test show that different concentrations of this substance did not have significant toxicity on glioblastoma cells and also spheroid formation was performed in the presence of this carbon dot.

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