Geri Dön

Synthesis, characterization, and hyperthermia studies of thermosensitive hydrogels associated with magnetic nanoemulsions

Başlık çevirisi mevcut değil.

  1. Tez No: 597736
  2. Yazar: AYBALA USTA
  3. Danışmanlar: DR. RAMAZAN ASMATULU
  4. Tez Türü: Doktora
  5. Konular: Makine Mühendisliği, Mechanical Engineering
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2018
  8. Dil: İngilizce
  9. Üniversite: Wichita State University
  10. Enstitü: Yurtdışı Enstitü
  11. Ana Bilim Dalı: Belirtilmemiş.
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 144

Özet

Özet yok.

Özet (Çeviri)

Targeted drug delivery is of great importance in cancer treatment and has become the interest of many scientists worldwide. Targeted drug delivery renders local treatment of cancerous cells possible without affecting healthy cells. Hydrogels are promising materials to be used in targeted drug delivery systems due to their biocompatible nature and injectable behavior whereby they can be used to load drugs. However, considering that not all the drugs are water soluble, entrapment of some drugs in hydrogels is not practical in terms of poor drug solubility and burst drug release. An oil phase can be considered as a drug-carrying agent, and entrapment of this oil phase into the hydrogel would make it possible for the in-situ injection of a dissolved drug into the oil phase. Moreover, incorporation of hydrogels with magnetic nanoparticles can create a double effect, making hyperthermia treatment possible and also controlling the flow of magnetic nanoparticles out of the concerned region using a hydrogel matrix. In this study, oil-in-water (O/W)-type nanoemulsions were prepared using a combination of black seed oil (which is known to cause apoptosis via a p-53 dependent mechanism), water, and Triton X-100 and Span-80 surfactants. Three different oil percentages and three different surfactant percentages were tested, and the stability behavior of these nanoemulsions were investigated and compared. Dynamic light scattering analysis and zeta potential measurements were conducted for determining particles sizes and surface charges of the nanoemulsions. The most stable nanoemulsion with the smallest diameter and lowest polydispersity index (PDI) was used in the synthesis of nanoparticle-added magnetic nanoemulsion hydrogels (MNHs) for the hyperthermia study. Results have indicated that time, concentration, and magnetic field strength (MFS) can significantly affect the heating ability of the samples, which can be promising candidates for further hyperthermia studies.

Benzer Tezler

  1. Yeni nesil core-shell kompozit malzemelerin karakterizasyonu vehedeflenebilir kanser ilacı salım sistemi uygulamaları

    Characterization of new generation core-shell composite materials and targetable cancer drug delivery system applications

    AYŞEGÜL YILDIRIM

    Yüksek Lisans

    Türkçe

    Türkçe

    2020

    BiyokimyaMuğla Sıtkı Koçman Üniversitesi

    Moleküler Biyoloji ve Genetik Ana Bilim Dalı

    DR. ÖĞR. ÜYESİ YASEMİN İSPİRLİ DOĞAÇ

  2. Manyetik demir oksit (Fe3O4) nanopartikülleri ile desteklenmiş gözenekli biyopolimer malzemelerin kanser tedavisi için geliştirilmesi

    Development of porous biopolymer materials supported with magnetic iron oxide (Fe2O3) nanoparticles for cancer therapy

    SAYNUR ARSLAN

    Yüksek Lisans

    Türkçe

    Türkçe

    2024

    Metalurji MühendisliğiSivas Cumhuriyet Üniversitesi

    Metalurji ve Malzeme Mühendisliği Ana Bilim Dalı

    DOÇ. DR. KERİM EMRE ÖKSÜZ

  3. Süperparamanyetik demir oksit nanopartikülleri içeren biyoaktif camların sol-jel yöntemi ile sentezi ve karakterizasyonu

    Synthesis and characterization of superparamagnetic iron oxide nanoparticlecontaining bioactive glasses by sol-gel method

    MEHMET SAATCİ

    Yüksek Lisans

    Türkçe

    Türkçe

    2023

    Metalurji MühendisliğiManisa Celal Bayar Üniversitesi

    Metalurji ve Malzeme Mühendisliği Ana Bilim Dalı

    PROF. DR. AYLİN MÜYESSER DELİORMANLI

  4. Iron based magnetic nanoparticles: Synthesis using different production methods, encapsulation with silica/graphene, characterization and performance tests

    Demir esaslı manyetik nanopartiküller: Farklı metotlar kullanarak sentezlenmesi, silika/grafen ile enkapsülasyonu, karakterizasyonu ve performans testleri

    SIDDIKA MERTDİNÇ ÜLKÜSEVEN

    Doktora

    İngilizce

    İngilizce

    2023

    Metalurji Mühendisliğiİstanbul Teknik Üniversitesi

    Metalurji ve Malzeme Mühendisliği Ana Bilim Dalı

    PROF. DR. MUSTAFA LUTFİ ÖVEÇOĞLU

    DOÇ. DR. DUYGU AĞAOĞULLARI

  5. Synthesis, characterization and biocompatibility tests of magnetic nanoparticles

    Manyetik nanopartiküllerin sentezlenmesi, karakterizasyonu ve biyouyumluluk testlerinin gerçekleştirilmesi

    AYSA AZMOUDEH

    Yüksek Lisans

    İngilizce

    İngilizce

    2023

    Metalurji Mühendisliğiİstanbul Teknik Üniversitesi

    Metalurji ve Malzeme Mühendisliği Ana Bilim Dalı

    DOÇ. DR. DUYGU AĞAOĞULLARI