Biyomedikal uygulamalar için flor yüklü poli (D,L) laktat membran üretimi
Production of fluoride loaded poly (D,L) lactide membranes for biomedical applications
- Tez No: 84239
- Danışmanlar: PROF. DR. ERHAN PİŞKİN
- Tez Türü: Yüksek Lisans
- Konular: Kimya Mühendisliği, Chemical Engineering
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 1999
- Dil: Türkçe
- Üniversite: Hacettepe Üniversitesi
- Enstitü: Fen Bilimleri Enstitüsü
- Ana Bilim Dalı: Kimya Mühendisliği Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 74
Özet
ABSTRACT Under concept of this thesis; biodegradable, fluoride loaded poly-(D,L)-lactide membranes are prepared in order to use in biomedical applications, especially in the dental area, against caries and for the demineralization of the enamel surface. Fluoride release and degradation behavior of these membranes in the artificial saliva is studied with different parameters. Surface structures of the membranes are examined via Scanning Electron Microscope (SEM). The fluoride particles are found to be dispersed homogeneous inside the membrane. It is observed that NaF particles are accumulated over the surface a result of the first load. In this study, in vitro degradation behavior of the membranes in the artificial saliva is examined no significant degradation is observed after 15 days of period. In the next phase of the study; fluoride release from the membranes are studied. As the first parameter fluoride/polymer ratio is chosen and different ratios are loaded to a polymer with a specific molecular weight. Burst effect of fluoride release is observed as a result of the accumulated NaF over surface in the first measurements. In the following observations, it is determined that more fluoride is released from the membrane that has a higher ratio of fluoride/polymer, until the end of the experiments. The fluoride release is significant in the first week and after this time, no significant release is observed. The effect of molecular weight of the polymers to fluoride release is also studied. Fluoride release is observed for 5 polymers with different molecular weights but same fluoride/polymer ratio. Degradation is not significant in the affective fluoride release period, so it is thought that no effect of degradation can occur on fluoride release from membranes.
Özet (Çeviri)
ABSTRACT Under concept of this thesis; biodegradable, fluoride loaded poly-(D,L)-lactide membranes are prepared in order to use in biomedical applications, especially in the dental area, against caries and for the demineralization of the enamel surface. Fluoride release and degradation behavior of these membranes in the artificial saliva is studied with different parameters. Surface structures of the membranes are examined via Scanning Electron Microscope (SEM). The fluoride particles are found to be dispersed homogeneous inside the membrane. It is observed that NaF particles are accumulated over the surface a result of the first load. In this study, in vitro degradation behavior of the membranes in the artificial saliva is examined no significant degradation is observed after 15 days of period. In the next phase of the study; fluoride release from the membranes are studied. As the first parameter fluoride/polymer ratio is chosen and different ratios are loaded to a polymer with a specific molecular weight. Burst effect of fluoride release is observed as a result of the accumulated NaF over surface in the first measurements. In the following observations, it is determined that more fluoride is released from the membrane that has a higher ratio of fluoride/polymer, until the end of the experiments. The fluoride release is significant in the first week and after this time, no significant release is observed. The effect of molecular weight of the polymers to fluoride release is also studied. Fluoride release is observed for 5 polymers with different molecular weights but same fluoride/polymer ratio. Degradation is not significant in the affective fluoride release period, so it is thought that no effect of degradation can occur on fluoride release from membranes.
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