In vivo assessment of toxicity of anti-retroviral drug azidothymidine in charles foster rats
Başlık çevirisi mevcut değil.
- Tez No: 918761
- Danışmanlar: DR. R.K.SINGH
- Tez Türü: Yüksek Lisans
- Konular: Belirtilmemiş.
- Anahtar Kelimeler: antiretroviral drug, azidothymidine, hematotoxicity, hepatotoxicity, in vivo, rats
- Yıl: 2008
- Dil: İngilizce
- Üniversite: Chhatrapati Shahu Ji Maharaj University
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 64
Özet
Özet yok.
Özet (Çeviri)
Azidothymidine (AZT), also termed as Zidovudine is a drug widely used in the treatment of HIV/AIDS. It is one of the first antiretroviral medicines that functions by hindering the reverse transcriptase enzyme, which HIV uses to replicate its genetic material. With initial approval in 1980s, it was used to diminish the progress of HIV infection and lessen the threat of AIDS. In this thesis study, the in vivo toxic effects of Azidothymidine (AZT) were investigated in Charles Foster rats. Six male and six female rats, with body weights from 100 to 300 grams were given a dose of 270 mg/kg AZT over 28 days and changes in hematological, biochemical, and histopathological parameters were observed in the Control and Treated groups. The findings showed that although the body weight of both male and female rats decreased, the decline was greater in the females. In comparison to the control, platelet counts of AZT treated male rats significantly increased, while the levels were significantly decreased in treated female rats. This disparity, which is supported by lower Hb levels in females but an unexpected rise in Hb in males, suggests that AZT may have a gender-dependent hematotoxic effect. Furthermore, mean corpuscular hemoglobin (MCH), MCV, and RBC counts displayed patterns in line with platelet responses. In biochemical parameters analysis, hepatic markers such as total protein (TP), albumin (ALB), alkaline phosphatase (ALP), and total bilirubin (TBIL) increased in both male and female AZT-treated rats confirming the AZT-contributed hepatotoxicity in experimental rats. The histopathological results were in accordance with biochemical outcomes, where liver, kidney, heart, lung, spleen, and brain inflammation validated the potential systemic toxicity in AZT treated rats. Absolute organ weights further demonstrated differential responses with female rats showing weight reductions only in brain, liver, and spleen, whereas male rats exhibited decreased weights in all major organs after AZT treatment. The findings supported that although AZT developed hematotoxicity and systemic toxicity in both male and female rats, the effects were more drastic in female rats emphasizing the need of genderdependent adjustment of dosages. Further research should focus on minimizing the side effects of the drug by conducting experiments on large number of samples including both the genders and by administering various AZT dosages for diverse intervals of time.
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