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Identification of predominant hepatitis c virus genotype in Turkish population

Türk toplumunda baskın olarak görülen hepatit c virüsü genotipinin belirlenmesi

  1. Tez No: 112598
  2. Yazar: FUNDA ŞAR
  3. Danışmanlar: PROF. DR. MEHMET ÖZTÜRK
  4. Tez Türü: Yüksek Lisans
  5. Konular: Biyoloji, Biology
  6. Anahtar Kelimeler: Hepatitis C Virus (HCV), genotyping, subtype lb, NS5B, Southern Turkey, full length, Turkish HCV-lb isolate. IV
  7. Yıl: 2001
  8. Dil: İngilizce
  9. Üniversite: İhsan Doğramacı Bilkent Üniversitesi
  10. Enstitü: Mühendislik ve Fen Bilimleri Enstitüsü
  11. Ana Bilim Dalı: Biyoloji Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 118

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Özet (Çeviri)

ABSTRACT IDENTIFICATION OF PREDOMINANT HEPATITIS C VIRUS GENOTYPE IN TURKISH POPULATION Funda ŞAR M.S. in Molecular Biology and Genetics Supervisor: Prof. Dr. Mehmet ÖZTÜRK July, 2001 Hepatitis C virus (HCV) is a major cause of acute and chronic hepatitis, leading to cirrhosis and hepatocellular carcinoma. Approximately 170 millions of person are chronically infected with HCV worldwide. HCV is an enveloped positive stranded RNA virus with 9.5 kb genome. The error-prone replication of HCV leads to its highly heterogeneous nature. There are 6 main genotypes and around 70 subtypes. The genotypes and subtypes of HCV have different prevalence rates and geographical distributions. They also differ in clinical manifestations, such as response to interferon treatment and disease progression. The identification of genotype distribution is of scientific importance because of its help in understanding of epidemiology of HCV and the clinical implications of the genotypes. In a previous study, conducted in our laboratory, the predominant genotype of HCV in South and Southeast Anatolia regions of Turkey was determined as subtype lb with 91% prevalence. Subtype la, 2a and 4 were also present with lower prevalences, 6.3%, 1.3%, 1.3%, respectively. The high prevalence rate of subtype lb and limitations of genotyping from 5' UTR in discrimination between subtype la from subtype lb lead to confirmation of these results from another region of HCV genome. In this study, to confirm the results of the III «SHSSSTJSfflprevious study we sequenced part of NS5B region and constructed phylogenetic tree. The results of this study were in concordance with the former study, indicating the predominant genotype as subtype lb in South and Southeast Anatolia regions of Turkey. After identification of subtype lb as the predominant genotype, a Turkish HCV-lb isolate was sequenced. Cloning and the partial sequence of HCV-lb isolate was performed by Aslı Öztan and in this study, we obtained the complete nucleic acid sequence of a Turkish HCV-lb isolate. It comprises 9361 nucleotides, including 306 nucleotides of 5' UTR, a single long open reading frame of 9033 nucleotides, and 22 nucleotides of 3' UTR. By sequence comparisons, we characterized the Turkish HCV- lb isolate.

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