Glial tümörlü hastalarda immünolojik değerlendirme ve CD95 (FAS) ekspresyonu
CD95 (FAS) expression and immunological evaluation in patients
- Tez No: 118126
- Danışmanlar: Belirtilmemiş.
- Tez Türü: Tıpta Uzmanlık
- Konular: Nöroşirürji, Onkoloji, Neurosurgery, Oncology
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2002
- Dil: Türkçe
- Üniversite: İstanbul Üniversitesi
- Enstitü: Cerrahpaşa Tıp Fakültesi
- Ana Bilim Dalı: Nöroşirürji Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 63
Özet
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Özet (Çeviri)
SUMMARY About % 50 of CNS tumors are primary CNS tumors, % 90 of which is glial tumor, i the last literatures glial tumors are % 1,4 of all tumor cases, these tumors are an important ouse of tumor related deaths. Karnowski Performance Score of patients, location of tumors, infiltrative ehaviour of tumors and malignant character of tumors limits treatment of glial tumors. For ıese reasons researchers look for new treatment modalites. This indicate that glial tumor eatment will always be changed. In this times; treatment of high grade glial tumors classically combination therapy rhich consist of surgery, radiation therapy and chemotherapy and increasing knowledge of enetic and immunologic or sciences creates new treatment alternative. In the light of these sciences, the point that we reach in gene therapy and nmunotherapy is hopefull. In our study, we examine patient with high grade glial tumors that opereted in itanbul Universty Cerrahpaşa Medical Faculty Neurosurgery Clinic retrospectively and the atients that operated in last year also worked with genetic and immunologic profiles. At the end of study we did not see statistically important difference in the nmune profiles between normal population and the patients. But it is seen that there is an nportant differance in the CD95 of lymphocites of peripheric blood between our patients and ontrol groups and also patient with other patologies. We discussed prognosis and teatment modalities of high grade glial tumors in ıe light of these results. 56
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