Siklosporinin kardiyovasküler risk faktörlerine olan etkisinin tavşanlarda araştırılması
Effect of Cyclosporine on cardiovascular risk factors in rabbits
- Tez No: 118532
- Danışmanlar: PROF.DR. OKTAY OYMAK
- Tez Türü: Tıpta Uzmanlık
- Konular: Kardiyoloji, Cardiology
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2002
- Dil: Türkçe
- Üniversite: Erciyes Üniversitesi
- Enstitü: Tıp Fakültesi
- Ana Bilim Dalı: İç Hastalıkları Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 89
Özet
Özet yok.
Özet (Çeviri)
Cardiovascular mortality and morbidity is the major cause of death in the United ates, other industrialized countries and also in Turkey. When we look at the transplant cipients which is a minor group of the population, cardiovascular complications is the major luse of death in many industrialized countries. In Turkey it is the second most common tuse of death. The economic burden of cardiovascular disease to the society is enormous. In e transplant recipients, the cardiovascular complications cause person's death, graft lost and e lost of the money and time used for transplantation and graft survival. Today, prevention ems better than treatment and there is a great effort to reduce cardiovascular risk. For the population the major risk factors for atherosclerosis are dyslipidemia, ^pertension, tobacco use and diabetes mellitus. Other risk factors include physical inactivity, jesity, family history of coronary heart disease, gender, alcohol consumption and sycho logical factors. In transplant recipients, besides from above mentioned risk factors,.obably there are many other risk factors for this group. The medications that these people ive to use for prevention of graft rejection may be one of the risk factor. Today, ^perhomocysteinemia is an established but newly recognized important cardiovascular risk ictor. Hyperhomocysteinemia is common in transplant recipients. Cyclosporine-A is a îlective immunosuppressive drug used in transplantation and in some immunological iseases. It is believed cyclosporine -A can cause cardiovascular risk for chronic users,.ccording to some textbooks cyclosporine's effect on lipid metabolism is undetermined but :cent research showed a lipid increasing effect. Also recently, some authors reported that yclosporine can cause hyperhomocysteinemia but others could not find such an effect. jiother fact is that, all these researches are clinically made among transplant recipients. We ecided to conduct an experimental research to determine cyclosporine's effect on lipid and omocysteine metabolism. Twenty New Zealand white male rabbits are selected as suitable experimental animals. )aily subcutaneous cyclosporine is administered 10 mg/kg for the first 10 days and 20 mg/kg arice weekly for the next 3 weeks. Rabbit plasma cyclosporine-A level was controlled on day 0 and 4th. week of the study. Eight parameters ( total cholesterol, LDL cholesterol, HDL holesteroL triglyceride, lipoprotein-a, homocysteine, BUN, creatinin ) were studied on the eginning, at the 10th. day and 4th. week of cyclosporine treatment, and end of the 8th week. Tie blood is taken from the ear veins of the rabbits. The research is planned to be in twoıges. In the first 4 weeks cyclosporine's effect on homocysteine and lipid levels is amined, in the second 4 weeks the effect after cyclosporine withdrawal is observed. As we compare the results, the most statistically significant change ( p0.05). For HDL cholesterol there js also no significant change (p>0,05). For lipoprotein-a there was a significant increase at b 8th week (p0,05). Mean eatinine values significantly increased (p
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