Geri Dön

1-[5-kloro-3H-benzoksazolin-2-on-3-il]asetil-2-(2/4-sübstitüe benzal) hidrazon türevlerinin sentezi, yapı aydınlatması ve biyolojik aktiviteleri üzerinde çalışmalar

Synthesis of 1-[5-chloro-3H-benzoxazoline-2-on-3-yl]acetyl-2(2/4-substituted benzal) hydrazone derivatives, their structure elucidations and biological activities

  1. Tez No: 163493
  2. Yazar: AHMET EMİN GECİKEN
  3. Danışmanlar: PROF.DR. ALİ ULVİ TOSUN
  4. Tez Türü: Yüksek Lisans
  5. Konular: Eczacılık ve Farmakoloji, Pharmacy and Pharmacology
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2006
  8. Dil: Türkçe
  9. Üniversite: Gazi Üniversitesi
  10. Enstitü: Sağlık Bilimleri Enstitüsü
  11. Ana Bilim Dalı: Farmasötik Kimya Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: Belirtilmemiş.

Özet

91 Table-2. The yields and the melting points of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2-(2/4-substituted benzal) hydrazone derivatives. CH2-C- NH-N=CH-^ The structure elucidation of the fourteen title compounds were done by means of their spectral analyses.92 The biological activity for anticonvulsant effectiveness were accomplished and results are given in Table 1. Table-1. Anticonvulsant activity results of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2- (2/4-substituted benzal)hydrazone derivatives. P<0.05, Dose: 100mg/kg intraperitonale As shown from Table-1, compounds 7 (2-OMe), 10 (2-Me), 11 (4-Me), 16 (4-Me) and 17 (4-NMe2) showed considerable anticonvulsant activity.91 Table-2. The yields and the melting points of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2-(2/4-substituted benzal) hydrazone derivatives. CH2-C- NH-N=CH-^ The structure elucidation of the fourteen title compounds were done by means of their spectral analyses.92 The biological activity for anticonvulsant effectiveness were accomplished and results are given in Table 1. Table-1. Anticonvulsant activity results of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2- (2/4-substituted benzal)hydrazone derivatives. P<0.05, Dose: 100mg/kg intraperitonale As shown from Table-1, compounds 7 (2-OMe), 10 (2-Me), 11 (4-Me), 16 (4-Me) and 17 (4-NMe2) showed considerable anticonvulsant activity.

Özet (Çeviri)

91 Table-2. The yields and the melting points of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2-(2/4-substituted benzal) hydrazone derivatives. CH2-C- NH-N=CH-^ The structure elucidation of the fourteen title compounds were done by means of their spectral analyses.92 The biological activity for anticonvulsant effectiveness were accomplished and results are given in Table 1. Table-1. Anticonvulsant activity results of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2- (2/4-substituted benzal)hydrazone derivatives. P<0.05, Dose: 100mg/kg intraperitonale As shown from Table-1, compounds 7 (2-OMe), 10 (2-Me), 11 (4-Me), 16 (4-Me) and 17 (4-NMe2) showed considerable anticonvulsant activity.91 Table-2. The yields and the melting points of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2-(2/4-substituted benzal) hydrazone derivatives. CH2-C- NH-N=CH-^ The structure elucidation of the fourteen title compounds were done by means of their spectral analyses.92 The biological activity for anticonvulsant effectiveness were accomplished and results are given in Table 1. Table-1. Anticonvulsant activity results of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2- (2/4-substituted benzal)hydrazone derivatives. P<0.05, Dose: 100mg/kg intraperitonale As shown from Table-1, compounds 7 (2-OMe), 10 (2-Me), 11 (4-Me), 16 (4-Me) and 17 (4-NMe2) showed considerable anticonvulsant activity.

Benzer Tezler

  1. Tez No

    225545

    Bazı 5-Kloro-6-(Sübstitüe Tiyazol-4-il)-2-Okso-3H-Benzoksazol türevlerinin sentezi ve COX inhibitör aktivitelerinin belirlenmesi üzerinde çalışmalar

    Studies on The Synthesis of 5-Chloro-6-(Substitue Thiazole-4-yl)-2-Oxo-3H-Benzoxazole derivatives and on identification of their COX inhibitory activities

    ŞÖLEN URLU

    Yüksek Lisans

    Türkçe

    Türkçe

    2007

    Eczacılık ve FarmakolojiGazi Üniversitesi

    Farmasötik Kimya Ana Bilim Dalı

    PROF.DR. SERDAR ÜNLÜ

  2. Tez No

    193113

    Bazı 2-benzoksazolinon bileşiklerinin sentezi ve analjezik etkileri üzerinde çalışmalar

    Synthesis of some 2-benzoxazolinone compounds and the studies on their analgesic activities

    FATMA BİLGEN BELDÜZ

    Yüksek Lisans

    Türkçe

    Türkçe

    2006

    Eczacılık ve FarmakolojiHacettepe Üniversitesi

    Farmasötik Kimya Ana Bilim Dalı

    PROF.DR. HAKKI ERDOĞAN

  3. Tez No

    116037

    Bazı 7-açil-3-sübstitüe-5-kloro-2-benzoksazolinon türevleri üzerinde çalışmalar

    Studies on some 7-acyl-3-substituted-5-chloro-2benzoxazolinone derivatives

    SULTAN BAYTAŞ

    Doktora

    Türkçe

    Türkçe

    2002

    Eczacılık ve FarmakolojiGazi Üniversitesi

    Farmasötik Kimya Ana Bilim Dalı

    DOÇ.DR. SERDAR ÜNLÜ

  4. Tez No

    16750

    Bazı benzoksazolon türevleri üzerinde sentez ve analjezik etki çalışmaları

    Başlık çevirisi yok

    H.GÜLHAN PİLLİ(AYYILDIZ)

    Doktora

    Türkçe

    Türkçe

    1991

    Eczacılık ve FarmakolojiHacettepe Üniversitesi

    PROF.DR. HAKKI ERDOĞAN

  5. Tez No

    687702

    Yeni imidazo[2,1-b]tiyazol türevlerinin sentezi, karakterizasyonu, analjezik ve antiinflamatuvar aktivitelerinin incelenmesi

    Synthesis, characterization and investigation of analgesic and antiinflammatory activities of new imidazo [2,1-b] thiazole derivatives

    OKŞAN SOYER CAN

    Doktora

    Türkçe

    Türkçe

    2021

    KimyaYıldız Teknik Üniversitesi

    Kimya Ana Bilim Dalı

    PROF. DR. BELKIZ BİLGİN ERAN

    PROF. DR. SERDAR ÜNLÜ

Geri Dön