Karragen ile multipartiküler ilaç taşıyıcı sistemlerin hazırlanması ve değerlendirilmesi
Başlık çevirisi mevcut değil.
- Tez No: 355210
- Danışmanlar: PROF. DR. BETÜL DORTUNÇ
- Tez Türü: Yüksek Lisans
- Konular: Eczacılık ve Farmakoloji, Pharmacy and Pharmacology
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 1998
- Dil: Türkçe
- Üniversite: Marmara Üniversitesi
- Enstitü: Sağlık Bilimleri Enstitüsü
- Ana Bilim Dalı: Farmasötik Teknoloji Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 147
Özet
Özet yok.
Özet (Çeviri)
A steady blood concentration can be achieved by the controlled release of the active drug from peroral solid preparations containing drugs that must be used chronically. Controlled drug delivery systems being multiparticular and not monolytic causes the transient time required to pass through gastrointestinal system less affected from the media. Drugs which have side effects to gastrointestinal system, irritants and which have a short half life can be formulated as multiparticular drug carrier systems by using natural, semi-synthetic and synthetic polymers. In this study beads were prepared by ionotropic gelation method by using the natural polymer carrageenan. Water soluble ( verapamil hydrochloride) and water insoluble ( ibuprofen) drugs were incorporated in beads. In this study fITst the identification, assay, solubility and release rate of the drugs were investigated. After determining the optimal conditions, carrageenan beads carrying verapamil hydrochloride and ibuprofen were prepared thereby regarding the factors affecting bead formation. Microscobic controls, particle size determination, encapsulation efficiency, release rates of drugs from beads were investigated. Results of these studies were statistically evaluated. Active drug, carrageenan, outer phase ( KCI ) concentrations, counterion type and outer phase ( KCI ) volume had no effect on the particle size of carrageenan beads carrying verapamil hydrochloride and ibuprofen. It was observed that encapsulation efficiency of verapamil hydrochloride was higher than that of ibuprofen. While drug concentration and counterion type had a significant effect on the encapsulation efficiency of carrageenan beads with verapamil hydrochloride, other factors ( carrageenan and outer phase concentrations, outer phase volume) had no significant effect. Drug and outer phase ( KCI ) concentrations had a significant effect on the encapsulation efficiency of carrageenan beads with ibuprofen, while outer phase volume had no significant effect. When the release rates of drugs from carrageenan beads were investigated it was observed that drug, carrageenan, outer phase ( KCI ) concentration, counterion type had a significant effect on the release rates of the drug but outer phase volume had no effect.
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