Studies on Lewis acid catalysed/mediated syntheses
Başlık çevirisi mevcut değil.
- Tez No: 400677
- Danışmanlar: PROF. DR. SANDY MCKILLOP
- Tez Türü: Doktora
- Konular: Biyomühendislik, Eczacılık ve Farmakoloji, Kimya, Bioengineering, Pharmacy and Pharmacology, Chemistry
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 1993
- Dil: İngilizce
- Üniversite: Unıversıty Of East Anglıa
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: Belirtilmemiş.
Özet
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Özet (Çeviri)
The work described in this thesis is divided into four parts. In the first part, benzyl chlorides or benzyl methyl ethers were reacted with hydrated ferric chloride in acetonitrile in a smooth Ritter type reaction and N-benzylacetamides were obtained in excellent yields. In the second part, a novel synthesis was attempted of flosequinan, which has valuable therapeutic activity in the treatment of heart failure and hypertension. Unfortunately, the crucial final step, a 1,4-dipolarcycioad^.ition reaction, failed. In part three, Diels-Alder reactions of itaconic anhydride with substituted 1,3-butadienes were re-examined in a 5.0 M lithium perchlorate-diethyl ether solution (LPDE) at ambient temperature and pressure. Rate enhancement was observed for methyl-substituted butadienes, but other butadienes gave only polymeric materials. In the last part of this study, reactions of i-{4-hydroxyaryl)-2-ketoximes, 4-HOArCH2C(=NOH)R,with phenyliodine(lii) bis(trifluoroacetate) (PIFA) in acetonitrile or ethanol were studied. This resulted in smooth intramolecular oxidative cyclisation and gave 1-oxa-2-azaspiro[4,5]deca-2,6,9-triene-8-ones in good to excellent yields.
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