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Engineering multifunctional hybrid nanomaterials for bioanalytical and biomedical applications

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  1. Tez No: 401301
  2. Yazar: İSMAİL ÖÇSOY
  3. Danışmanlar: PROF. WEIHONG TAN
  4. Tez Türü: Doktora
  5. Konular: Biyomühendislik, Biyoteknoloji, Bioengineering, Biotechnology
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2014
  8. Dil: İngilizce
  9. Üniversite: University of Florida
  10. Enstitü: Yurtdışı Enstitü
  11. Ana Bilim Dalı: Nanobilim ve Nanomühendislik Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 152

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Özet (Çeviri)

Multifunctional hybrid nanomaterials (NMs) have received considerable attention for use in variety of bioanalytical and biomedical applications. The multi-functions are provided by hybrid NMs composed of at least two different components. The hybrid NMs consisting of more than one domain may carry enhanced chemical and physical properties compared to single domain NMs. There is still a need to prepare new types of hybrid NMs and to develop alternative synthesis techniques for multifunctional hybrid NMs with superior properties compared to those of existing single and hybrid NMs produced via conventional methods. There is high demand for new multifunctional hybrid NMs used as efficient ionization and digestion substrates for mass spectrometry, enhanced antibacterial reagents and sensitive detection platforms in bioanalytics. This thesis discusses the synthesis, characterization and development of multifunctional hybrid NMs for bioanalytical and biomedical applications. For the first project, flower-shaped gold/manganese (II) oxide hybrids NMs (Au@MnO) were synthesized for use in metabolite extraction from cancer cell lysates. The nanoflower (Au@MnO) exhibited the best matrix properties for laser desorption and ionization mass spectrometry (LDI-MS). For the second project, trypsin-based flower-shaped NMs were developed to efficiently digest proteins in mass spectrometry (MS). Trypsin flower NMs hold several unique properties compared to trypsin itself in solution including lower digestion times, clear background, synergistic effect for efficient protein digestion and enzyme stability. For the third project, a simple and universal route was developed for the preparation of metal-graphene oxide (GO) heterostructures (Ag–GO, Au–GO, Cu–GO, Pt–GO, and Au/Cu/Pt–GO) with controllable nanoparticle size and shape using double-stranded DNA (dsDNA) as a template. We used DNA-directed Ag–GO hybrid nanostructures to develop a sensitive, simple, and reliable strategy for the detection of dopamine using zeta potential measurements. For the fourth project, we have developed DNA-directed silver (Ag) nanoparticles (NPs) grown on GO. These Ag@dsDNA@GO composites effectively decreased Xanthomonas perforans (X. perforans) cell viability in culture and in tomato plants without causing any phytotoxicity.

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