Micro/nano modification of peek surface for possible medical use
Başlık çevirisi mevcut değil.
- Tez No: 401344
- Danışmanlar: PROF. DR. M. E. HAMMADEH, PROF. DR. H. ABDUL-KHALIQ
- Tez Türü: Doktora
- Konular: Kardiyoloji, Çocuk Sağlığı ve Hastalıkları, Cardiology, Child Health and Diseases
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2013
- Dil: İngilizce
- Üniversite: Universität des Saarlandes
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Pediatri Ana Bilim Dalı
- Bilim Dalı: Kardiyoloji Bilim Dalı
- Sayfa Sayısı: 137
Özet
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Özet (Çeviri)
Cell adhesion and proliferation has high importance in the case of human implantation where the surface properties of the materials define the cell response. In this context, surface modifications of these implants were carried out by several groups where the nano and micro surface topographies are introduced to implant surfaces. However, surface chemistry may change depending on the chosen method during the modification process. Therefore, it may be helpful by keeping the surface chemistry identical in order to understand the cellular response to the implant materials in terms of the surface topographic features. In this context, surface modification of Polyetheretherketone (PEEK) was performed by laser and plasma treatment methods in terms of the micro and nano scale surface structuring in order to understand the endothelial cell response to the structured surfaces. Laser system was used to realize periodical structures while oxygen plasma system was used to create one dimensional nano structures over the surfaces. A microlens array was used to realize the periodical structures over planar PEEK and plasma treated PEEK substrates where it can create around four thousand identical structures over the substrate surface. However, due to the non-identical surface chemistries of PEEK surface types after treatments, thin alpha alumina layer was deposited over the substrates surface by pulsed laser deposition technique in order to perform identical surface chemistries. Generated surfaces were analyzed for their surface properties and their cellular behaviors to the endothelial cells were tested in-vitro. Additionally, generated PEEK surfaces were compared for their cellular responses with commercially available alumina plates, with one dimensional Al/Al2O3 core/shell nanowires which were deposited on glass substrates by chemical vapor deposition and with their periodically structured surface types by laser system. It was observed by the entire experiments, combination of micro and nano surface structures for alumina and alumina coated PEEK substrates have high influence on the endothelial cell proliferation in comparison to other generated surface structures. Besides, it was observed that the tendency of the cell proliferation rates for each comparable surface (for example: Al/Al2O3 core/shell nanowires to nano structured and alumina coated PEEK surface) are indicating high similarity. This result can bring up a new point of view for the medical applications where the implant materials with low melting temperature can be processes by the investigated experimental methods in comparison to the high melting temperature materials with the same surface topography and the chemistry.
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