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Comprehensive association analysis of selected single nucleotide polymorphisms with cancer prevalence in Japanese elderly population

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  1. Tez No: 402733
  2. Yazar: CÜNEYD PARLAYAN
  3. Danışmanlar: PROF. MASAAKI MURAMATSU
  4. Tez Türü: Doktora
  5. Konular: Biyoteknoloji, Biotechnology
  6. Anahtar Kelimeler: Cancer risk, SNPs, miR-SNPs, gastric cancer, pancreatic cancer, acute leukemia
  7. Yıl: 2014
  8. Dil: İngilizce
  9. Üniversite: Tokyo Medical and Dental University
  10. Enstitü: Yurtdışı Enstitü
  11. Ana Bilim Dalı: Biyomedikal Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 133

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Özet (Çeviri)

Most common genetic variation in human genome is single nucleotide polymorphisms (SNPs) and these genetic modifications may affect cancer susceptibility. We analyzed several SNPs in genes encoding cytokines, micro RNAs (miRs), metabolic disease related proteins or genes to replicate previously conducted studies and obtain deeper understanding of how these SNPs or associated genes may influence cancer development in Japanese population. Our samples were consecutive autopsy cases registered in the Japanese SNPs for geriatric research (JG-SNP) data base, and also each available sample investigated by genotyping. Cancer samples were systematically reviewed, pathologically verified and assessed with respect to selected polymorphisms. We categorized our findings into three main parts: a. rs11614913 on miR-196a2 (p = 0.873, p = 0.737, p = 0.990) and rs2910164 on miR-146a (p = 0.383, p = 0.887, p = 0.446) lacked the association with overall cancer risk, however CC genotype in rs11614913 was associated with gastric cancer (p = 0.040). b. rs1800469 (C-509T) on TGFβ1, C allele was associated with overall cancer (p = 0.012, p = 0.030, p = 0.022). Furthermore, rs334354 (IVS7+24G>A) on TGFβR, G allele was protective allele in pancreatic cancer (p = 0.024). AA + CT combined genotype of both ligand and receptor genes was also associated with overall cancer (p = 0.018). c. Among examined 30 SNPs which are associated with metabolic diseases, rs1800470 (P10L) on TGFβ1 was associated with overall cancer risk (p = 0.007, p = 0.039, p = 0.005). The rs2243250 on ESRI was associated with increased acute leukemia risk (p = 0.008), however, rs2077647 on IL4 was associated with decreased acute leukemia risk (p = 0.007). We found some evidence that rs11614913, rs1800469, rs334354, rs1800470, rs2243250, rs2077647 polymorphisms may influence cancer development in elderly Japanese population. Our results warrant further confirmations by larger sample numbers and functional analysis.

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