Investigation of a ring fragmentation reaction for the synthesis of tethered aldehyde ynones and medium sized cyclic ynones and ynolides
Başlık çevirisi mevcut değil.
- Tez No: 403443
- Danışmanlar: Prof. MATTHIAS BREWER
- Tez Türü: Doktora
- Konular: Kimya, Chemistry
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2015
- Dil: İngilizce
- Üniversite: The University of Vermont (UVM)
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 375
Özet
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Özet (Çeviri)
The fragmentation of γ-silyloxy-β-hydroxy-α-diazoesters to provide tethered aldehyde ynoates was discovered and developed in Prof. Brewer's laboratory. This reaction is a Lewis acid mediated heterolytic cleavage of the Cβ-Cγ bond of a γ-silyloxy-β-hydroxy-α-diazocarbonyl functional group array contained in a ring compound. This dissertation describes a further study of this ring fragmentation reaction and application of this fragmentation to the preparation of synthetically useful organic molecules. The purpose of this dissertation work was three fold. The first objective was to extend this ring fragmentation reaction to the synthesis of tethered aldehyde ynones by fragmenting various γ-silyloxy-β-hydroxy-α-diazo ketone compounds. The second objective was to develop a new way to make medium size rings by fragmenting fused bicyclic γ-silyloxy-β-hydroxy-α-diazo ketones. The final goal was to use this reaction to make medium size ynolides by fragmentation of fused bicyclic γ-silyloxy-β-hydroxy-α-diazo esters to provide core structures for medium-size lactones which are synthetically challenging to make using other available methods.
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