Geri Dön

Zeeman geri düzeltmeli grafit fırın atomik absorpsiyon spektrometrisi ile selenyumun biyolojik materyallerden analizi üzerinde çalışmalar

The Analysis of selenium in various biological materials by Zeeman background corrected graphite furnace atomic absoption spectrometry

  1. Tez No: 48124
  2. Yazar: ŞÜKRAN BARIN
  3. Danışmanlar: DOÇ.DR. NURAN ÖZALTIN
  4. Tez Türü: Yüksek Lisans
  5. Konular: Eczacılık ve Farmakoloji, Pharmacy and Pharmacology
  6. Anahtar Kelimeler: Selenyum, Zeeman Gerizemin Düzeltmeli Grafit Fırın Atomik Absorpsiyon Spektrometrisi, Biyolojik Materyalden Selenyum Analizi, Selenyum Analizinde Matriks Değiştiriciler, Selenyum, Zeeman Gerizemin Düzeltmeli Grafit Fırın Atomik Absorpsiyon Spektrometrisi, Biyolojik Materyalden Selenyum Analizi, Selenyum Analizinde Matriks Değiştiriciler
  7. Yıl: 1996
  8. Dil: Türkçe
  9. Üniversite: Hacettepe Üniversitesi
  10. Enstitü: Sağlık Bilimleri Enstitüsü
  11. Ana Bilim Dalı: Belirtilmemiş.
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 73

Özet

ABSTRACT In this study it has been showed that Zeeman Background Corrected Graphite Furnace Atomic Absorption Spectrometric method, which has been developed for the analysis of selenium in biological materials such as serum, plasma, erythrocyte, whole blood and breast milk, was a reliable, rapid and accurate one which hadn't required any other proprocesses. Since there is a very short range between the essential and toxic levels of selenium which is an essential trace element for organism, the analysis of selenium at ppb level in biological materials is being important. Optimum matrix modifier, pyrolysis and atomization temperatures were determined as Pd+Mg(N03)2, 1200 °C and 2200 °C respectively, in the optimization studies carried out with various matrix modifiers. The optimum Pd and Mg(N03)2 concentrations were found as 300 ppm and 600 ppm respectively. Drying step was achieved by three steps as 70, 120 and 250 °C with temperature ramping programme. Raising to pyrolysis was made by temperature ramping while raising to atomization temperature was achieved at zero second in order to provide the maximum power heating. Cleaning process was made by two step. As a result of these optimization studies the developed furnace programme and the other analysis parameters we used were observed to be in accordance with Stabilized Temperature Platform Furnace conditions. Since the calibration curves of direct calibration and standard addition methods were found in parellel, the direct calibration curve method was prefered in the analysis. Detection limit, linearity and VIhastalıkların teşhisinde, geliştirilen yöntem ile elde edilen nicel sonuçların önemli bir basamak oluşturabileceği görülmektedir. Ayrıca bu hasta gruplarından sağlanacak biyolojik materyallerde, bu yöntem ije^j^yenl^selenyum analizi yapılarak tedavi aşamasında da etkili olabileceği düşünülmektedir.

Özet (Çeviri)

ABSTRACT In this study it has been showed that Zeeman Background Corrected Graphite Furnace Atomic Absorption Spectrometric method, which has been developed for the analysis of selenium in biological materials such as serum, plasma, erythrocyte, whole blood and breast milk, was a reliable, rapid and accurate one which hadn't required any other proprocesses. Since there is a very short range between the essential and toxic levels of selenium which is an essential trace element for organism, the analysis of selenium at ppb level in biological materials is being important. Optimum matrix modifier, pyrolysis and atomization temperatures were determined as Pd+Mg(N03)2, 1200 °C and 2200 °C respectively, in the optimization studies carried out with various matrix modifiers. The optimum Pd and Mg(N03)2 concentrations were found as 300 ppm and 600 ppm respectively. Drying step was achieved by three steps as 70, 120 and 250 °C with temperature ramping programme. Raising to pyrolysis was made by temperature ramping while raising to atomization temperature was achieved at zero second in order to provide the maximum power heating. Cleaning process was made by two step. As a result of these optimization studies the developed furnace programme and the other analysis parameters we used were observed to be in accordance with Stabilized Temperature Platform Furnace conditions. Since the calibration curves of direct calibration and standard addition methods were found in parellel, the direct calibration curve method was prefered in the analysis. Detection limit, linearity and VIhastalıkların teşhisinde, geliştirilen yöntem ile elde edilen nicel sonuçların önemli bir basamak oluşturabileceği görülmektedir. Ayrıca bu hasta gruplarından sağlanacak biyolojik materyallerde, bu yöntem ije^j^yenl^selenyum analizi yapılarak tedavi aşamasında da etkili olabileceği düşünülmektedir.

Benzer Tezler

  1. Bazı organometalik bileşiklerin tepe boşluklu tek damla mikro özütleme ve grafit fırınlı atomik absorpsiyon spektrometri ile seçimli tayini için yöntem geliştirilmesi

    Method development for the selective determination of some organometallic compounds by headspace single drop micro extraction and graphite furnace atomic absorption spectrometry

    DENİZ YURTSEVER SARICA

    Doktora

    Türkçe

    Türkçe

    2011

    HastanelerGazi Üniversitesi

    Kimya Ana Bilim Dalı

    PROF. DR. REHBER A. TÜRKER

  2. Cikletlerdeki kurşun, arsenik ve bakırın atomik absorbsiyon spektrofotometrik yöntemle tayini

    Determination of lead, arsenic and copper in chewing-gum by atomic absorbtion spektrophotometer

    ERDAL KENDÜZLER

    Yüksek Lisans

    Türkçe

    Türkçe

    1997

    Eğitim ve ÖğretimGazi Üniversitesi

    Kimya Eğitimi Ana Bilim Dalı

    DOÇ. DR. ZİYA KILIÇ

  3. Atış artıklarında et-AAS ile antimon analizi ve gözlenen analitik problemler

    Determination of antimony in gun shot residues (GSR) by et-AAS and analytical problems

    NEVRA FİDAN

    Yüksek Lisans

    Türkçe

    Türkçe

    2009

    Adli TıpUludağ Üniversitesi

    Kimya Bölümü

    YRD. DOÇ. DR. BELGİN İZGİ

  4. Bizmut, indiyum, kurşun ve antimonun etasas ile tayinlerinde uygun ortam düzenleyici madde sisteminin araştırılması

    Başlık çevirisi yok

    ORHAN ACAR

    Doktora

    Türkçe

    Türkçe

    1996

    KimyaGazi Üniversitesi

    Kimya Ana Bilim Dalı

    PROF.DR. ALİ REHBER TÜRKER

  5. Sezyum atomik gazında optik pompalama ve koherent etkilerin araştırılması

    Investigation of optical pumping and coherent effects in cesium atomic gas

    ERSOY ŞAHİN

    Doktora

    Türkçe

    Türkçe

    2014

    Fizik ve Fizik Mühendisliğiİstanbul Teknik Üniversitesi

    Fizik Mühendisliği Ana Bilim Dalı

    PROF. DR. GÖNÜL ÖZEN