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Nazofarinks kanserli hastaların takibinde PET-CT, MR ve histopatolojinin korelasyonu

The correlation of pet-CT, MRİ and histopathology in the follow-up of patients with nasopharyngeal carcinoma

  1. Tez No: 487059
  2. Yazar: SEMİH AK
  3. Danışmanlar: PROF. DR. ÜMİT TUNÇEL
  4. Tez Türü: Tıpta Uzmanlık
  5. Konular: Kulak Burun ve Boğaz, Otorhinolaryngology (Ear-Nose-Throat)
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2017
  8. Dil: Türkçe
  9. Üniversite: Sağlık Bilimleri Üniversitesi
  10. Enstitü: Dr. Abdurrahman Yurtaslan Ankara Onkoloji Eğitim ve Araştırma Hastanesi
  11. Ana Bilim Dalı: Kulak Burun Boğaz Hastalıkları Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 69

Özet

Çalışmamızda klniğimiz nazofarinks kanseri tanısıyla radyoterapi ya da radyoterapi-kemoterapi kombine tedavisi almış 40 hastanın 2015-2017 yılları arasındaki takiplerinde PET-CT, MR ve histopatolojik verileri analiz edildi. MR' da kontrast tutulan lezyon görülüp görülmemesi ile PET-BT SuvMax ölçümleri arasında istatistiksel olarak anlamlı bir birliktelik saptanmadı. Tek değişkenli analizler sonucunda p

Özet (Çeviri)

PET-CT, MRI and histopathologic data of 40 patients, treated with only radiotherapy or radiotherapy and chemotherapy combination for the diagnosis of nasopharyngeal carcinoma in our clinic between 2015-2017 years, were analyzed. No statistically significant association was found between PET-BT SUV-max measurements and whether or not the lesion keeping contrast substance in the MRI. After single-variable analyses, all the variables were taken into multi-variate logictic regression model as risk factor ccandidates. T stage as having the least effect in differentiating cases with recurrence and cases without recurrence were kept out of the model in the latter step in the first model, the age variable that had the least effect in differentiating the groups were excluded in tthe latter model. On the other hand, in the Final model there is only SUVmax Nfx variable and recurrence risk in those with PET-BT SUVmax Nfx value above 4,58 was statstically significantly 7,667 times more than those with that value below 4,58 (%95 confidence interval: 1.2998-45.289) (p=0,025). While MR is superior in defining the size of local tumor in the newly diagnosed patients, PET-CT has given more diagnostic accuracy in defining nodal and distant metastases in newly diagnosed patients. However,in the evaluation after treatment, PET-CT is especially important. It is more seccessful in differentiating post-chemoradiotherapy fibrosis and residual tumor and recurrence.Additional metabolic information obtained by PET-CT are more superior in improvement of clinical outcomes, follow-up and treatment planning of especially people with locoregional disease. Eventuaally, PET-CT has shown more accuracy than MRI in showing recurrence in the region of primary tumor. MRI and PET-CT are complementary to each other in the presence of clinical doubt. Even if there are different reports in the literature related to this information, if it is correlated to histopathology in our study, it has been seen that PET-CCT was superior to MRI in defining the recurrence. For the patients under clinical doubt, taking MRI in short intervals and evaluating them with PET-CT will be the proper approach.

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