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Düşük doz radyoterapinin tavşanlardaki taze osteokondral allogreft uygulamaları üzerindeki etkileri

The Effects of low dose radiation on fresh osteochondral allografts in rabbits

  1. Tez No: 70866
  2. Yazar: H. UĞUR GÖNÇ
  3. Danışmanlar: DOÇ. DR. ERDAL CİLA
  4. Tez Türü: Tıpta Uzmanlık
  5. Konular: Ortopedi ve Travmatoloji, Orthopedics and Traumatology
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 1998
  8. Dil: Türkçe
  9. Üniversite: Gazi Üniversitesi
  10. Enstitü: Tıp Fakültesi
  11. Ana Bilim Dalı: Ortopedi ve Travmatoloji Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 68

Özet

56 SUMMARY in this study we examined the effects of low dose radiotherapy on fresh osteochondral allografts. Medial femoral condyles taken from California rabbits were transplanted to white New Zeland rabbits as fresh osteochondral allografts. We had three groups: Group I (n = 5) was fresh osteochondral allografts aione. In Group II (n = 7) we performed 5 daily fractions of 100 cGy (totai 500 cGy) local radiotherapy after transplantation. In Group III the grafts were irradiated with singie dose 1500 cGy before transplantation. After twelve weeks of follow-up the results were evaluated according to knee motion, radiographic changes, synovial hypertrophy and cartilage degeneration. Cartilage degeneration was scored after macroscopic and histological examination. Pannus formation was present in three rabbits in Group I. We did not see any pannus formation in the other groups which radiotherapy was administered. Cartilage degeneration and hypocellularity of chondrocytes were more pronounced in Group III than Group I but there was no significant difference between Group II and ill; as well as Group I and II. Delayed union of the graft was seen in three rabbits in Group II and one rabbit in Group III. We concluded that low dose radiotherapy with fractions was effective in preventing pannus formation after fresh osteochonral allografts but a longer foiiow-up period is needed to observe its effects on cartilage degeneration, in vitro high single dose radiotherapy was found to be ineffective in preventing cartilage degeneration.

Özet (Çeviri)

56 SUMMARY in this study we examined the effects of low dose radiotherapy on fresh osteochondral allografts. Medial femoral condyles taken from California rabbits were transplanted to white New Zeland rabbits as fresh osteochondral allografts. We had three groups: Group I (n = 5) was fresh osteochondral allografts aione. In Group II (n = 7) we performed 5 daily fractions of 100 cGy (totai 500 cGy) local radiotherapy after transplantation. In Group III the grafts were irradiated with singie dose 1500 cGy before transplantation. After twelve weeks of follow-up the results were evaluated according to knee motion, radiographic changes, synovial hypertrophy and cartilage degeneration. Cartilage degeneration was scored after macroscopic and histological examination. Pannus formation was present in three rabbits in Group I. We did not see any pannus formation in the other groups which radiotherapy was administered. Cartilage degeneration and hypocellularity of chondrocytes were more pronounced in Group III than Group I but there was no significant difference between Group II and ill; as well as Group I and II. Delayed union of the graft was seen in three rabbits in Group II and one rabbit in Group III. We concluded that low dose radiotherapy with fractions was effective in preventing pannus formation after fresh osteochonral allografts but a longer foiiow-up period is needed to observe its effects on cartilage degeneration, in vitro high single dose radiotherapy was found to be ineffective in preventing cartilage degeneration.

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