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The effects of diet and regular mixers on alcohol pharmacokinetics

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  1. Tez No: 759876
  2. Yazar: ASENA AVCI
  3. Danışmanlar: PROF. ATHOLL JOHNSTON
  4. Tez Türü: Yüksek Lisans
  5. Konular: Adli Tıp, Forensic Medicine
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2017
  8. Dil: İngilizce
  9. Üniversite: Queen Mary Unıversıty Of London
  10. Enstitü: Yurtdışı Enstitü
  11. Ana Bilim Dalı: Adli Tıp Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: Belirtilmemiş.

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Özet (Çeviri)

Background: Consumption of alcoholic drinks with mixer is increasing in 'diet' varieties. These could possibly empty more quickly from the stomach and thus rise the rate of alcohol absorption while 'regular' ones including sugar has reverse effect. Methods: In this study, 7 healthy volunteers were studied twice in randomized order. On each session, they drunk a vodka drink (37.5 % ABV), prepared with either 'regular' beverage including sugar (138.6 kcal), or 'diet' beverage including artificial sweetener (1.32 kcal). Their breath alcohol concentrations were taken every 15 minutes during 3 hours with lion alcolmeter® SD-400 and lion alcolmeter® 500. Simultaneously, their breath samples for gastric emptying measurement were taken in breath bags in the same time interval. These breath samples were analyzed with an IRIS® instrument to get t1/2 and tlag parameters. Results: Both the peak ethanol breath ethanol concentration (44072.3 vs. 38662.9 g/L) and the area under the breath ethanol curve between 0 and 180 minutes (507.467.6 vs. 448.150.8 units) were greater with diet coke. Gastric half-emptying time and lag phase time were calculated from the 13C percent dose recovery values measured by IRIS® instrument with nonlinear regression analysis. Gastric half-emptying time was less for the diet drink than the regular drink (86.37.8 vs. 88.417.1 min) but tlag was greater for diet drink than the regular drink (48.19.6 vs. 46.115.7 min). Conclusions: Consumption of artificial sweeteners for sucrose by mixing them with alcoholic drinks may have an effect on the rate of gastric emptying and the breath alcohol response.

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