Design and development of drug-loaded mofs
Başlık çevirisi mevcut değil.
- Tez No: 771784
- Danışmanlar: DR. MİCHAł LESZCZYńSKİ
- Tez Türü: Yüksek Lisans
- Konular: Biyoteknoloji, Biotechnology
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2022
- Dil: İngilizce
- Üniversite: Warsaw University of Technology
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 53
Özet
The fabrication methods, usage areas, and research about metal-organic frameworks (MOFs) are exponentially increased in these several decades due to their unique and adjustable physical and chemical properties. Nowadays, it is possible to use MOFs in many fields, such as bioimaging, biosensing, biocatalysts, degeneration of toxic molecules, adsorption, antibacterial applications storage, and/or separation of gas molecules, and drug delivery mechanisms. This experimental work, Design and Development of Drug-loaded MOFs, provides information about several MOF structures such as MOF-5, ZIF-8, and HKUST-1, in terms of the fabrication method found in literature, accepted as the traditional method, and their drug loading capacity. Mechanochemical MOFs synthesis methods were applied for all samples during this research project, via a ball mill machine under various frequencies with various time durations with the presence and absence of drug and initiator molecules. Sample examinations of all powders showed the traditional fabrication methods are matching with our results, for various MOF fabrications and it is possible to improve and discover other initiator molecules. The XRD results of Trial-3 showed that it is possible that ibuprofen, the drug itself, can be used for MOF fabrication without the need for any initiators. Also, similar compounds such as benzoic acid, acetic acid, and phenylacetic acid showed various successful results. NMR results showed the ZIF-8 structure formed without the initiator ethanol contains 11.25% of drug molecules, which is considered a good result. As demonstrated by the experimental result within this thesis, it is possible to use alternative molecules to initiate a MOF formation reaction between the metal ion and the organic linker, even drugs themselves in the case of ibuprofen. This research shows new opportunities for further studies that investigate the MOF fabrication with various organic linkers or usage of the drug molecules for such purpose.
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