Fabrication of apatite- wollastonite glass ceramic scaffolds by 3d printing
Başlık çevirisi mevcut değil.
- Tez No: 796614
- Danışmanlar: DR. OANA BRETCANU
- Tez Türü: Yüksek Lisans
- Konular: Bilgisayar Mühendisliği Bilimleri-Bilgisayar ve Kontrol, Makine Mühendisliği, Computer Engineering and Computer Science and Control, Mechanical Engineering
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2015
- Dil: İngilizce
- Üniversite: University of Newcastle upon Tyne
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 84
Özet
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Özet (Çeviri)
Skeletal defects, which are caused by trauma, disease, tumours or congenital defects, are healed by biomaterials with implantation into body. Bone has the ability to regenerate itself but it is up to small sizes. If the injuries are larger than the regeneration abilities of bone, then a biomaterial replacement is needed. The most popular solution are synthetic implants known as scaffolds that include the in vitro seeding and adhesion of cells on to porous structures and supply temporary service for stem cells to lead them differentiate into desired tissue1 . A scaffold which directs cells to form functional tissue is usually used to replace into bone to supply tissue ingrowth2 . Types of scaffold are ceramics, polymers and composites but it has been seen that ceramic-based scaffolds are brittle and polymers do not have high mechanical strength to mimic bone structure. However, glass-ceramic scaffolds are bioactive and have higher mechanical strength, osteoconductivity and osteoinductivity. Not only the material of scaffold is important, but also the fabrication technique of scaffold is crucial. 3D printing fabrication method allows to design desired dimensions and controlling mechanical properties1, 3 . In present study, A-W glass ceramic scaffolds were fabricated by 3D printing technique and they were sintered to consolidate their structures. Bioactivity of A-W scaffolds were observed performing the bioactivity tests analysing the biodegradation rate and pH variation. At last, characterisation of the scaffolds was performed under SEM. However, biodegradation rate varies with respect to soaking days. After 1st week soaking period, it has been analysed that mass weight of scaffolds started to increase and scanning electron microscope characterisation results showed apatite-like layer started to form since 14 days of soaking in SBF.
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