A genome-wide association study to identify candidate genes associated with DAG score in a commercial sheep breeding population
Başlık çevirisi mevcut değil.
- Tez No: 798240
- Danışmanlar: Belirtilmemiş.
- Tez Türü: Yüksek Lisans
- Konular: Biyomühendislik, Genetik, Zooloji, Bioengineering, Genetics, Zoology
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2018
- Dil: İngilizce
- Üniversite: Aberystwyth University / Prifysgol Aberystwyth
- Enstitü: Prifysgol Aberystwyth
- Ana Bilim Dalı: Yurtdışı Enstitü
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 41
Özet
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Özet (Çeviri)
Undoubtedly, sheep have significant effect on the global agricultural economy supplying meat, milk, skins and wool. However parasitic, metabolic and production diseases of sheep can dramatically affect the welfare and productivity of animals and increase the cost related to the treatment. Dagginess is an important welfare concern and represents a major cost to sheep breeders due to reducing the value of wool and productivity and increasing the risk of flystrike. Dags, also known as faecal or breech soiling, refer to accumulation of faecal material on the wool of the breech area. A variety of environmental and genetic factors can lead to dagginess: including feed quality and level of feed intake, changes in diets, fungal endotypes, gastrointestinal parasites, the length of wool, tail and breech bareness. Moreover, weaning weight may also have an impact on dag score because weaning is the critical time to significantly affect animal welfare. At weaning, the immune system of lambs is not fully developed and they are more susceptible to disease, especially internal parasites which mainly results in diarrhoea. Weaning weight influences gastrointestinal development. The genetic architecture regulating dagginess is poorly known and the understanding of exact genetic mechanisms of dags would provide the potential for genomic selection to improve the trait. This study aimed to identify single nucleotide polymorphisms (SNPs) and candidate genes associated with dagginess and weaning weight. A genome-wide association study in a population of UK sheep was performed using TASSEL software (v5.0) in a mixed model. The study revealed the presence of 8 novel significant SNPs located on OAR 3, 7, 9, 17, 20, 25 that were associated with dagginess and 13 novel SNPs on OAR 1, 2, 7, 15, 20, 26 and X for weaning weight. There were no common SNPs or gene locations between two traits. For dagginess, the genes functioning on faecal consistency; CPNE8, PRICKLE1, KCNMA1 and DLG5 were detected as the strongest candidates. On the other hand, TRNAS-GGA, CADM2, PAX5 and NRXN3, which play a role in body weight, were detected good candidates for weaning weight. These genes could be investigated for future search to further scrutinise the genetic background of the traits. Increasing the sample size and using a much denser distribution of SNPs throughout the genome would lead to further improvement in sheep GWAS.
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