Bazı hidrazid-hidrazonlar üzerinde çalışmalar
Başlık çevirisi mevcut değil.
- Tez No: 80391
- Danışmanlar: PROF.DR. NEDİME ERGENÇ
- Tez Türü: Yüksek Lisans
- Konular: Eczacılık ve Farmakoloji, Pharmacy and Pharmacology
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 1986
- Dil: Türkçe
- Üniversite: İstanbul Üniversitesi
- Enstitü: Sağlık Bilimleri Enstitüsü
- Ana Bilim Dalı: Farmasötik Kimya Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 74
Özet
- 63 ÖZET Literatürde hidrazid hidrazon yapısında ve değişik farmakolojik etkide birçok maddenin yer alması ve malonani- lik asid hidrazidinin hidrazon türevlerinin tüberkülostatik etki gösterdiğinin bildirilmesi (, 6), bizi hidrazid hid razon yapısında sekiz yeni bileşiği sentez etmeye yöneltmiş tir. İlgili bileşikler p-karbetoksifenilhidrazonomezoksalik asid dihidraz idinin (a) (2) sırası ile benzaldehid, 4-bromo- benzaldehid, 4-klorobenzaldehid, 2,6-diklorobenzaldehid, 2-hidroksibenzaldehid, 4-metoksibenzaldehid, 3-etoksi
Özet (Çeviri)
- 65 - SUMMARY The observation that several hydrazide hydrozones showing various pharmacological activities appeared in the literature, and hydrazone derivatives of malonanilic acid hydrazide possessed antituberculosis activity ( 6) led to the synthesis of eight" new hydrazide hydra zones. The in volved compounds were prepared by the condensation of p-car- bethoxyphenylmesoxalic acid dihyirazide (a) (2) with benzal- dehyde, 4-bromobenz aldehyde, 4- chlorobenzaldehyde, 2,6-di- chlorobenzaldehyde, 2-hydroxybenzaldehyde, 4-methoxybenz al dehyde, 3-ethoxy-4-hydroxybenzaldehyde and 3,4-methylenedi- oxybenzaldehyde respectively. The synthesized compounds were treated with hydrazine hydrate for the determination of some of their properties. Consequently, the -CH=ÎT- linkage was hydrolized due to the alkaline effect of hydrazine hydrate leading to the forma tion of the starting substance (a) and the corresponding aldehyde. The starting substance was isolated from the medium and the aldehyde reacted with the excess of hydrazine hydrate to yield the corresponding azine (when compound IV was used 2,6-dichlorobenzylidene hydrazine was also detec ted). When treated with hydrazine hydrate the compounds also underwent a reductive cleavage during which benzocaine was formed.- 66 - Treatment of the compounds with 70 % HpSO, also re sulted in the hydrolysis of the ~CH=N- linkage. The sta.rting substance (a) and the corresponding aldehyde were the de tectable products of this reaction. Spectroscopic methods (UV, IR, MER. and Mass Spectro metry) were employed in addition to elemental analysis for the structure elucidation of the- synthesized compounds and the data obtained confirmed the expected molecular structures. With the expectation that they might demonstrate anti- tuberculous activity, all the compounds were evaluated for their action against Mycobacterium tuberculosis, H^7R strain, using 1UH as the standard but no remarkable activity was encountered.
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