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Omeprazol'ün fenilefrinle kastırılmış fare korpus kavernozumu üzerinde gevşetici etkisinin mekanizması

The mechanism of the relaxant effect of omeprazole on mouse corpus cavernosum precontracted with phenylephrine

  1. Tez No: 158354
  2. Yazar: PEYMAN ERTUĞ UÇAR
  3. Danışmanlar: PROF.DR. SERPİL ÖNDER
  4. Tez Türü: Doktora
  5. Konular: Eczacılık ve Farmakoloji, Pharmacy and Pharmacology
  6. Anahtar Kelimeler: Mouse corpus cavernosum tissue, Omeprazole, Phenylephrine, Proton pump xu
  7. Yıl: 2004
  8. Dil: Türkçe
  9. Üniversite: Çukurova Üniversitesi
  10. Enstitü: Sağlık Bilimleri Enstitüsü
  11. Ana Bilim Dalı: Farmakoloji Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 71

Özet

ÖZET Omeprazol'ün Fenilefrin ile Kastırılmış Fare Korpus Kavernozumu Üzerinde Gevşetici Etkisinin Mekanizması izole fare korpus kavernozum dokusunda hem fenilefrin ile oluşturulan aktif tonus üzerinde hem de ESS ile oluşturulan nitrerjik cevaplar üzerinde omeprazol'ün etkisi araştırıldı. Bir eti agonist olan fenilefrin (10"7M, 5xl

Özet (Çeviri)

ABSTRACT The Mechanism of The Relaxant Effect of Omeprazole on Mouse Corpus Cavernosum Precontracted with Phenylephrine The effect of omeprazol on the phenylephrine and EFS-induced responses were investigated in the corpus cavernosum isolated from mice. An od-agonist phenylephrine (10'7 M, 5xl0“7 M, 10”6 M, 5xl0'6 M, 10'5 M, 5xl05 M and 10“4 M) and EFS (4, 8, 16, 32, 64Hz; 30V, 0.5ms, 15sec) stimulation in the presence of NO-synthase inhibitor L-NOARG (10”4 M), caused concentration and frequency dependent contractions, respectively. These contractions were partially inhibited in the presence of omeprazol, a proton pump inhibitor. High K+ (40mM) caused a sustained contraction. This response was reproducible. In the tissue precontracted with phenylephrine, both EFS (2, 4, 8Hz; 30V, 0.5ms, 15sec) and omeprazol (5x1 0s M and 10"4 M) led to reproducible concentration- and frequency-dependent relaxations, respectively. Phenyleprine-induced contraction was not changed in the presence of low Ca2+ (0.75mM) while contraction was augmented in the presence of high Ca2+ (3mM) level. EFS-induced contraction was not affected by low or high Ca2+ levels. In the presence of omeprazol, EFS-induced contraction was inhibited. In the low Ca2+ level, inhibitor effect of omeprazol was augmented while this effect was reduced in the presence of high Ca2+ level. In the presence of omeprazol, high K* (40mM)-induced contraction was partially inhibited. When Ca2+ level was lowered, inhibitor effect of omeprazol on the contraction was augmented. However, in the presence of high Ca2+ level this inhibitor effect was decreased. Similar findings were observed in the tissue precontracted with phenylephrine. Phenylephrine- and EFS-induced contractions were inhibited in the K* -free medium. This inhibition was increased in the presence of omeprazol. EFS-induced relaxation of the tissue precontracted with phenylephrine was not affected in the presence of omeprazol. When the Ca2+ level was decreased or in the absence of Ca2+, omeprazol-induced relaxation was not changed. Omeprazol-induced relaxation was decreased in the K* -free medium. However, in the absence of both K* and Ca2+, this relaxation was reversed. Taken together, these findings suggest that omeprazol may modulate mobilization or release of the intracellular Ca2+, affecting the contractu mechanism in the corpus cavernosum isolated from mice.

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